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公开(公告)号：EP2705037A1
公开(公告)日：2014-03-12
申请号：EP12717331.8
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , LI, Volkhart Min-Jian
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5365
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The invention relates to novel substituted imidazopyridines and imidazopyridazines, to a method for the production thereof, to the individual or combined use thereof for the treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP2705037B1
公开(公告)日：2016-06-22
申请号：EP12717331.8
申请日：2012-05-02
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , LI, Volkhart Min-Jian
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5365
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D487/04
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3.发明公开SUBSTITUIERTE ANNELLIERTE PYRIMIDINE UND IHRE VERWENDUNG 有权替代品ANNELLIERTE PYRIMIDINE UND IHRE VERWENDUNG
公开(公告)号：EP2751106A1
公开(公告)日：2014-07-09
申请号：EP12766292.2
申请日：2012-08-30
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , LINDNER, Niels , VAKALOPOULOS, Alexandros , TERSTEEGEN, Adrian
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
摘要： The present application relates to new substituted annellated pyrimidines, a method for the production thereof, the use thereof in isolation or in combination for the treatment and/or prophylaxis of diseases, and the use thereof to produce medicines for the treatment and/or prophylaxis of diseases, more particularly for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的环状嘧啶，其生产方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。
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4.发明公开SUBSTITUIERTE, ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG 有权SUBSTITUIERTE，ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG
公开(公告)号：EP2802587A2
公开(公告)日：2014-11-19
申请号：EP13700985.8
申请日：2013-01-08
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , PAULSEN, Holger , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The invention relates to novel substituted, annulated imidazoles and pyrazoles, methods for the production thereof, the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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5.发明公开HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482A1
公开(公告)日：2014-05-07
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
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公开(公告)号：EP2751106B1
公开(公告)日：2017-10-18
申请号：EP12766292.2
申请日：2012-08-30
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , LINDNER, Niels , VAKALOPOULOS, Alexandros , TERSTEEGEN, Adrian
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P9/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
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7.发明授权SUBSTITUIERTE, ANNELLIERTE IMIDAZOLE UND PYRAZOLE UND IHRE VERWENDUNG 有权SUBSTITUIERTE，ANNELLIERTE IMIDAZOLE UND PRARAZOLE和IHRE VERWENDUNG
公开(公告)号：EP2802587B1
公开(公告)日：2017-09-06
申请号：EP13700985.8
申请日：2013-01-08
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , PAULSEN, Holger , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
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8.发明授权HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482B1
公开(公告)日：2016-07-20
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
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公开(公告)号：EP2802592A1
公开(公告)日：2014-11-19
申请号：EP13700288.7
申请日：2013-01-10
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , GRIEBENOW, Nils , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , TERSTEEGEN, Adrian , VAKALOPOULOS, Alexandros
IPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61P9/10 , A61P9/12
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The application relates to novel substituted annulated pyrimidines and triazines, methods for the production thereof, the use thereof alone or in combination for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP2822951B1
公开(公告)日：2017-07-26
申请号：EP13712162.0
申请日：2013-03-05
发明人： FOLLMANN, Markus , STASCH, Johannes-Peter , REDLICH, Gorden , VAKALOPOULOS, Alexandros , LANG, Dieter , WUNDER, Frank , HÜBSCH, Walter , HAHN, Michael
IPC分类号： C07D487/04 , A61K31/522 , A61P9/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
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