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1.发明公开Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same 失效含有这些疫苗，其制备方法及其使用方法伪狂犬病毒突变体。
公开(公告)号：EP0232798A2
公开(公告)日：1987-08-19
申请号：EP87101134.2
申请日：1987-01-28
发明人： Kit, Malon , Kit, Saul
IPC分类号： C12N7/01 , C12N7/00 , C12N15/38 , A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , C12N15/00 , C12N2710/16722 , C12N2710/16734
摘要： The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a re- sutt. animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.
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2.发明授权Thymidine kinase-negative temperature resistant bovine herpesvirus-1 mutant as a vaccine against infectious bovine rhinotracheitis 失效甲基激素阴性耐温箱Hervirus-1突变体作为疫苗对感染性牛血清白蛋白
公开(公告)号：EP0119025B1
公开(公告)日：1989-09-13
申请号：EP84301158.6
申请日：1984-02-23
发明人： Kit, Saul
IPC分类号： A61K39/245 , A61K39/265 , C12N5/00
CPC分类号： A61K39/265 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/16734
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3.发明公开Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same 失效感染性牛鼻气管炎病毒的突变体，含有它们的疫苗，其制备方法和它们的用途。
公开(公告)号：EP0316658A1
公开(公告)日：1989-05-24
申请号：EP88118266.1
申请日：1988-11-02
发明人： Kit, Malon , Kit, Saul , Otsuka, Haruki
IPC分类号： C12N15/38 , A61K39/265
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/265 , A61K2039/5254 , A61K2039/552 , C12N15/00 , C12N2710/16722 , C12N2710/16734
摘要： Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.
摘要翻译： 传染性牛鼻气管炎病毒（牛疱疹病毒1型）的突变体含有缺失和/或插入突变在一个主要的病毒糖蛋白基因，谋求确实由病毒基因编码的无抗原性多肽的生产，感染性牛鼻气管炎疫苗含有相同，对于方法 生产同样的方法，并使用相同的。 与合成的突变体接种的动物不产生抗体的病毒糖蛋白，可以从感染牛传染性鼻气管炎病毒野毒株的动物血清学区分。
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4.发明公开Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of the same 失效牛疱疹病毒-1的胸苷激酶缺失突变体，含有针对牛鼻气管炎和它们的制备和使用过程中的相同疫苗。
公开(公告)号：EP0226029A1
公开(公告)日：1987-06-24
申请号：EP86115455.7
申请日：1986-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/265
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , C12N2710/16734 , Y10S424/813 , Y10S424/822 , Y10S930/224
摘要： Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.
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5.发明公开
公开(公告)号：EP0149040A2
公开(公告)日：1985-07-24
申请号：EP84113424.0
申请日：1984-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/245 , C12N7/04 , C12N15/38
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N2710/16734 , Y10S424/822
摘要： Temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of mutagen-induced mutation and temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of a deletion in the tk gene, vaccines containing same, methods for production of same and methods for use of same.
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6.发明授权Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same 失效感染性牛鼻气管炎病毒的突变体，含有它们的疫苗，其制备方法和它们的用途。
公开(公告)号：EP0316658B1
公开(公告)日：1994-03-09
申请号：EP88118266.1
申请日：1988-11-02
发明人： Kit, Malon , Kit, Saul , Otsuka, Haruki
IPC分类号： C12N15/38 , A61K39/265
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/265 , A61K2039/5254 , A61K2039/552 , C12N15/00 , C12N2710/16722 , C12N2710/16734
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7.发明公开Herpesvirus-based viral vector which expresses a foot & mouth disease virus epitope 失效基于基于HERPESVIRUS的病毒载体，其表达出一种病毒性病毒病毒
公开(公告)号：EP0471457A3
公开(公告)日：1992-03-04
申请号：EP91306646.0
申请日：1991-07-22
IPC分类号： C12N15/86 , A61K39/135 , C12N15/42
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/16643 , C12N2770/32122
摘要： The present invention relates to a herpesvirus-based viral vector which expresses a foot and mouth disease epitope on the surface of virus-infected cells and on the surface of the virus particles. The viral vector of the present invention is useful, inter alia , as either a live or killed viral vaccine against foot and mouth disease.
摘要翻译： 本发明涉及一种表达病毒感染细胞表面上和病毒颗粒表面上的口蹄疫表位的基于疱疹病毒的病毒载体。 本发明的病毒载体尤其可用作针对口蹄疫的活的或灭活的病毒疫苗。
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8.发明公开Herpesvirus-based viral vector which expresses a foot & mouth disease virus epitope 失效疱疹病毒-Vektor，der ein Epitope des Maul- und Klauenseuchenviruses exprimiert。
公开(公告)号：EP0471457A2
公开(公告)日：1992-02-19
申请号：EP91306646.0
申请日：1991-07-22
IPC分类号： C12N15/86 , A61K39/135 , C12N15/42
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/16643 , C12N2770/32122
摘要： The present invention relates to a herpesvirus-based viral vector which expresses a foot and mouth disease epitope on the surface of virus-infected cells and on the surface of the virus particles. The viral vector of the present invention is useful, inter alia , as either a live or killed viral vaccine against foot and mouth disease.
摘要翻译： 本发明涉及一种表达病毒感染细胞表面上和病毒颗粒表面上的口蹄疫表位的基于疱疹病毒的病毒载体。 本发明的病毒载体尤其可用作针对口蹄疫的活的或灭活的病毒疫苗。
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9.发明公开Thymidine kinase-negative temperature resistant bovine herpesvirus-1 mutant as a vaccine against infectious bovine rhinotracheitis 失效Thymidinkinase-Negativ-TemperaturbeständigerRinder疱疹病毒1突变体alk Vakzin gegeninfektiöseRinder-Rhinotracheitis。
公开(公告)号：EP0119025A2
公开(公告)日：1984-09-19
申请号：EP84301158.6
申请日：1984-02-23
发明人： Kit, Saul
IPC分类号： A61K39/245 , A61K39/265 , C12N5/00
CPC分类号： A61K39/265 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/16734
摘要： Described are thymidine kinase negative temperature resistant mutants of bovine herpesvirus effective in inducing resistance to infectious bovine rhinotracheitis, methods for their production, methods for maintaining them in viable form, and methods for administering them to animals in immunologically effective doses to induce reistance to infectious bovine rhinotracheitis.
摘要翻译： 描述了有效诱导感染性牛鼻气管炎的抗性的牛疱疹病毒的胸苷激酶耐温突变体，其生产方法，将其保持在活的形式的方法，以及以免疫有效剂量给予动物以诱导感染性牛的抗性的方法 鼻气管炎。
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10.发明授权
公开(公告)号：EP0149040B2
公开(公告)日：2002-05-22
申请号：EP84113424.0
申请日：1984-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/245 , C12N7/04 , C12N15/38
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N2710/16734 , Y10S424/822
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