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公开(公告)号：EP2825671A1
公开(公告)日：2015-01-21
申请号：EP13761285.9
申请日：2013-03-13
发明人： O'GARRA, Anne , BLOOM, Chloe , BERRY, Matthew, Paul Reddoch , WILKINSON, Robert , BANCHEREAU, Jacques, F. , CHAUSSABEL, Damien , PASCUAL, Maria, Virginia
CPC分类号： C12Q1/6883 , A61K31/133 , A61K31/455 , A61K31/496 , A61K31/4965 , C12Q1/68 , C12Q2600/118 , C12Q2600/158 , G01N33/48 , G01N33/68 , G01N33/6893 , G01N2333/35 , G01N2800/26 , G01N2800/52
摘要： The present invention includes methods for early detection of a treatment response in a patient suspected of being infected with
Mycobacterium tuberculosis . Changes in the blood transcriptome are detectable within two weeks of the initiation of antituberculosis therapy.-
2.发明公开BLOOD TRANSCRIPTIONAL SIGNATURES OF ACTIVE PULMONARY TUBERCULOSIS AND SARCOIDOSIS 审中-公开ACTIVE PULMONARTUBERKULOSE和结节病的转录BLOOD签字
公开(公告)号：EP2931923A1
公开(公告)日：2015-10-21
申请号：EP13863263.3
申请日：2013-12-13
发明人： O'GARRA, Anne , BLOOM, Chloe , BERRY, Matthew, Paul Reddoch , BANCHEREAU, Jacques, F. , CHAUSSABEL, Damien , PASCUAL, Maria, Virginia
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The present invention includes a method of determining a lung disease from a patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia comprising: obtaining a sample from whole blood of the patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia; detecting expression of (although not exclusive) six or more disease genes, markers, or probes selected from SEQ ID NOS.: 1 to 1446, wherein increased expression of mRNA of upregulated sarcoidosis, tuberculosis, lung cancer and pneumonia markers of SEQ ID NOS.: 1 to 1446 and/or decreased expression of mRNA of downregulated sarcoidosis, tuberculosis, lung cancer or pneumonia markers of SEQ ID NOS.: 1 to 1446 relative to the expression of the mRNAs from a normal sample; and determining the lung disease based on the expression level of the six or more disease markers of SEQ ID NOS.: 1 to 1446 based on a comparison of the expression level of sarcoidosis, tuberculosis, lung cancer, and pneumonia.
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3.发明公开DIAGNOSIS OF SYSTEMIC ONSET JUVENILE IDIOPATHIC ARTHRITIS THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 审中-公开诊断系统性爆发幼年特发性关节炎关于血液中的白细胞微阵列分析的
公开(公告)号：EP1941057A2
公开(公告)日：2008-07-09
申请号：EP06816451.6
申请日：2006-10-06
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) usin microarrays.
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4.发明公开
公开(公告)号：EP2341934A2
公开(公告)日：2011-07-13
申请号：EP09818386.6
申请日：2009-09-29
IPC分类号： A61K39/395 , A61P17/00 , A61P19/02 , A61P37/00
CPC分类号： C07K16/244 , A61K2039/505
摘要： The present invention includes compositions and methods for the treatment of autoimmune diseases by administering to a subject having an autoimmune disorder an effective amount of a therapeutic composition comprising a pharmaceutically acceptable carrier and at least one IL- 12 inhibitor, e.g., a blocking anti-IL-12 antibody or fragment thereof.
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公开(公告)号：EP1937846A2
公开(公告)日：2008-07-02
申请号：EP06814874.1
申请日：2006-09-15
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile of a suitable sample by screening for the presence of a differentially expressed SLE-associated gene isolated from a sample containing or suspected of containing a cell that can differentially express an SLE-associated gene.
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