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公开(公告)号：EP2825671A1
公开(公告)日：2015-01-21
申请号：EP13761285.9
申请日：2013-03-13
发明人： O'GARRA, Anne , BLOOM, Chloe , BERRY, Matthew, Paul Reddoch , WILKINSON, Robert , BANCHEREAU, Jacques, F. , CHAUSSABEL, Damien , PASCUAL, Maria, Virginia
CPC分类号： C12Q1/6883 , A61K31/133 , A61K31/455 , A61K31/496 , A61K31/4965 , C12Q1/68 , C12Q2600/118 , C12Q2600/158 , G01N33/48 , G01N33/68 , G01N33/6893 , G01N2333/35 , G01N2800/26 , G01N2800/52
摘要： The present invention includes methods for early detection of a treatment response in a patient suspected of being infected with
Mycobacterium tuberculosis . Changes in the blood transcriptome are detectable within two weeks of the initiation of antituberculosis therapy.-
2.发明公开BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开相比递延结核分支杆菌活性转录BLOOD签名INFECTION-
公开(公告)号：EP2519652A2
公开(公告)日：2012-11-07
申请号：EP10833713.0
申请日：2010-08-19
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting the patient gene expression dataset into one or more gene modules associated with Mycobacterium tuberculosis infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active Mycobacterium tuberculosis infection.
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3.发明公开BLOOD TRANSCRIPTIONAL SIGNATURES OF ACTIVE PULMONARY TUBERCULOSIS AND SARCOIDOSIS 审中-公开ACTIVE PULMONARTUBERKULOSE和结节病的转录BLOOD签字
公开(公告)号：EP2931923A1
公开(公告)日：2015-10-21
申请号：EP13863263.3
申请日：2013-12-13
发明人： O'GARRA, Anne , BLOOM, Chloe , BERRY, Matthew, Paul Reddoch , BANCHEREAU, Jacques, F. , CHAUSSABEL, Damien , PASCUAL, Maria, Virginia
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The present invention includes a method of determining a lung disease from a patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia comprising: obtaining a sample from whole blood of the patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia; detecting expression of (although not exclusive) six or more disease genes, markers, or probes selected from SEQ ID NOS.: 1 to 1446, wherein increased expression of mRNA of upregulated sarcoidosis, tuberculosis, lung cancer and pneumonia markers of SEQ ID NOS.: 1 to 1446 and/or decreased expression of mRNA of downregulated sarcoidosis, tuberculosis, lung cancer or pneumonia markers of SEQ ID NOS.: 1 to 1446 relative to the expression of the mRNAs from a normal sample; and determining the lung disease based on the expression level of the six or more disease markers of SEQ ID NOS.: 1 to 1446 based on a comparison of the expression level of sarcoidosis, tuberculosis, lung cancer, and pneumonia.
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4.发明公开BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开结核分枝tuberculosum BLUTTRANSKRIPTIONSSIGNATUR感染
公开(公告)号：EP2300823A2
公开(公告)日：2011-03-30
申请号：EP09771053.7
申请日：2009-06-25
申请人： Baylor Research Institute , The National Institute For Medical Research , Imperial College Healthcare NHS Trust
CPC分类号： G01N33/5695 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/60
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.
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5.发明公开DIAGNOSIS OF SYSTEMIC ONSET JUVENILE IDIOPATHIC ARTHRITIS THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 审中-公开诊断系统性爆发幼年特发性关节炎关于血液中的白细胞微阵列分析的
公开(公告)号：EP1941057A2
公开(公告)日：2008-07-09
申请号：EP06816451.6
申请日：2006-10-06
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) usin microarrays.
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6.发明公开GENE EXPRESSION SIGNATURES IN BLOOD LEUKOCYTES PERMIT DIFFERENTIAL DIAGNOSIS OF ACUTE INFECTIONS 审中-公开在急性感染的血液白细胞的鉴别诊断的基因表达特征
公开(公告)号：EP2057286A2
公开(公告)日：2009-05-13
申请号：EP07840869.7
申请日：2007-08-10
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.
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7.发明授权DIAGNOSIS OF METASTATIC MELANOMA AND MONITORING INDICATORS OF IMMUNOSUPPRESSION THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 有权诊断转移性黑色素瘤和监测IMMUNSUPPRESSIONSINDIKATOREN MITTTELS血液白细胞微阵列的
公开(公告)号：EP2080140B1
公开(公告)日：2013-04-24
申请号：EP07871360.9
申请日：2007-11-03
IPC分类号： G06F19/00
CPC分类号： G06F19/20 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G06F19/18
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8.发明公开DIAGNOSIS OF METASTATIC MELANOMA AND MONITORING INDICATORS OF IMMUNOSUPPRESSION THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 有权诊断转移性黑色素瘤和监测IMMUNSUPPRESSIONSINDIKATOREN MITTTELS血液白细胞微阵列的
公开(公告)号：EP2080140A2
公开(公告)日：2009-07-22
申请号：EP07871360.9
申请日：2007-11-03
IPC分类号： G06F19/00
CPC分类号： G06F19/20 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G06F19/18
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.
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9.发明公开DIAGNOSIS, PROGNOSIS AND MONITORING OF DISEASE PROGRESSION OF SYSTEMIC LUPUS ERYTHEMATOSUS THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 审中-公开诊断，预后和疾病进展系统性红斑狼疮的血液血液白细胞微阵列分析监测
公开(公告)号：EP1968610A2
公开(公告)日：2008-09-17
申请号：EP06839208.3
申请日：2006-12-09
CPC分类号： C12Q1/6883 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/24 , Y02A90/24 , Y02A90/26
摘要： The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
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10.发明公开MODULE-LEVEL ANALYSIS OF PERIPHERAL BLOOD LEUKOCYTE TRANSCRIPTIONAL PROFILES 审中-公开分析外周血白细胞转录概况ON模块级
公开(公告)号：EP1963533A2
公开(公告)日：2008-09-03
申请号：EP06848531.7
申请日：2006-12-09
CPC分类号： C12Q1/6883 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/24 , Y02A90/24 , Y02A90/26
摘要： The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into clusters; iteratively selecting gene expression values for one or more transcriptional modules by: selecting for the module the genes from each cluster that match in every disease or condition; removing the selected genes from the analysis; and repeating the process of gene expression value selection for genes that cluster in a sub-fraction of the diseases or conditions; and iteratively repeating the generation of modules.
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