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1.发明公开POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF 有权化合物的多晶形式PROLYLHYDROXYLASEHEMMER及其用途
公开(公告)号：EP2734504A1
公开(公告)日：2014-05-28
申请号：EP12817360.6
申请日：2012-07-23
发明人： KANG, Xinshan , LONG, Wei , ZHANG, Jianxi , HU, Yunyan , WANG, Yinxiang
IPC分类号： C07D217/26 , A61K31/472 , A61P3/10 , A61P7/06 , A61P9/12 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00
CPC分类号： C07D217/26 , A61K31/472 , C07B2200/13
摘要： The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.
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2.发明公开STABLE POLYMORPHIC FORMS OF COMPOUND AS HYPOXIA MIMETICS, AND USES THEREOF 审中-公开稳定多晶型形成了一个连接，HYPOXIEMIMETIKA及其用途
公开(公告)号：EP2736892A1
公开(公告)日：2014-06-04
申请号：EP12819230.9
申请日：2012-07-30
发明人： KANG, Xinshan , LONG, Wei , WANG, Fei , MA, Cunbo , ZHOU, Liufeng , HU, Yunyan , WANG, Yanping , CAO, Hong , WANG, Yinxiang , TAN, Fenlai
IPC分类号： C07D311/56 , A61K31/37 , A61P7/00
CPC分类号： C07D311/56
摘要： The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
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公开(公告)号：EP2454249B1
公开(公告)日：2018-09-19
申请号：EP10799353.7
申请日：2010-07-14
发明人： KANG, Xinshan , LONG, Wei , MA, Cunbo , WANG, Yanping , CAO, Hong , WANG, Yinxiang , TAN, Fenlai , HU, Yunyan
IPC分类号： C07D311/56 , C07D405/04 , A61K31/37
CPC分类号： A61K31/37 , C07D311/56 , C07D405/04
摘要： This invention relates to new compounds that can serve as hypoxia mimetics. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one of these compounds.
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4.发明授权POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF 有权化合物的多晶形式PROLYLHYDROXYLASEHEMMER及其用途
公开(公告)号：EP2734504B1
公开(公告)日：2016-09-14
申请号：EP12817360.6
申请日：2012-07-23
发明人： KANG, Xinshan , LONG, Wei , ZHANG, Jianxi , HU, Yunyan , WANG, Yinxiang
IPC分类号： C07D217/26 , A61K31/472 , A61P3/10 , A61P7/06 , A61P9/12 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00
CPC分类号： C07D217/26 , A61K31/472 , C07B2200/13
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公开(公告)号：EP2638036B1
公开(公告)日：2017-08-16
申请号：EP11839459.2
申请日：2011-11-09
发明人： KANG, Xinshan , LONG, Wei , MA, Cunbo , WANG, Yanping , SHEN, Xiaoyan , HU, Yunyan , TAN, Fenlai , WANG, Yinxiang
IPC分类号： C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D213/80 , C07D213/803 , C07D277/42 , C07D241/20 , C07D285/08 , C07D233/88 , C07D213/74 , C07D401/12 , C07D403/12 , A61K31/44 , A61K31/4178 , A61K31/444 , A61K31/433 , A61P3/08 , A61P3/10
CPC分类号： C07D417/14 , C07D213/74 , C07D213/80 , C07D213/803 , C07D233/88 , C07D241/20 , C07D277/42 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12
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公开(公告)号：EP2638036A1
公开(公告)日：2013-09-18
申请号：EP11839459.2
申请日：2011-11-09
发明人： KANG, Xinshan , LONG, Wei , MA, Cunbo , WANG, Yanping , SHEN, Xiaoyan , HU, Yunyan , TAN, Fenlai , WANG, Yinxiang
IPC分类号： C07D405/04 , C07D405/12 , C07D417/12 , C07D417/14 , C07D213/80 , C07D213/803 , C07D277/42 , C07D241/20 , C07D285/08 , C07D233/88 , C07D213/74 , C07D401/12 , C07D403/12 , A61K31/44 , A61K31/4178 , A61K31/444 , A61K31/433 , A61P3/08 , A61P3/10
CPC分类号： C07D417/14 , C07D213/74 , C07D213/80 , C07D213/803 , C07D233/88 , C07D241/20 , C07D277/42 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The compound of formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complex thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.
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