专利检索 ap:("Beijing Immunochina Pharmaceuticals Co., Ltd." OR "Shandong Jinsai Co., Ltd.") AND inv:"LU, Xin-An" 第 1 页

1.

发明公开
CHIMERIC ANTIGEN RECEPTOR TARGETING CD123 AND USE THEREOF 审中-公开

公开(公告)号：EP4265638A1

公开(公告)日：2023-10-25

申请号：EP21905330.3

申请日：2021-10-29

申请人： Beijing Immunochina Pharmaceuticals Co., Ltd. , Shandong Jinsai Co., Ltd.

发明人： HE, Ting , QI, Feifei , LU, Xin-An , DING, Yanping , LIANG, Mengmeng

IPC分类号： C07K16/28 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/867 , C12N5/10 , A61K39/00 , A61P35/02

摘要： Provided in the present invention is a single-chain antibody scFv that specifically binds to CD123, including an amino acid sequence selected from SEQ ID NOs: 56, 57, 58, 59, 60 and 61. Also provided is a chimeric antigen receptor targeting CD123, including an amino acid sequence selected from SEQ ID NOs: 65, 66, 67, 68, 69 and 70. Further provided are a nucleic acid molecule encoding the scFv or chimeric antigen receptor, a vector and cell containing the nucleic acid molecule, and the use of the antibody, chimeric antigen receptor, nucleic acid molecule, vector or cell in the preparation of a drug for treating tumor expressing CD123.