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公开(公告)号：EP4265638A1
公开(公告)日：2023-10-25
申请号：EP21905330.3
申请日：2021-10-29
发明人： HE, Ting , QI, Feifei , LU, Xin-An , DING, Yanping , LIANG, Mengmeng
IPC分类号： C07K16/28 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/867 , C12N5/10 , A61K39/00 , A61P35/02
摘要： Provided in the present invention is a single-chain antibody scFv that specifically binds to CD123, including an amino acid sequence selected from SEQ ID NOs: 56, 57, 58, 59, 60 and 61. Also provided is a chimeric antigen receptor targeting CD123, including an amino acid sequence selected from SEQ ID NOs: 65, 66, 67, 68, 69 and 70. Further provided are a nucleic acid molecule encoding the scFv or chimeric antigen receptor, a vector and cell containing the nucleic acid molecule, and the use of the antibody, chimeric antigen receptor, nucleic acid molecule, vector or cell in the preparation of a drug for treating tumor expressing CD123.
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公开(公告)号：EP4261228A1
公开(公告)日：2023-10-18
申请号：EP21902604.4
申请日：2021-12-07
发明人： LU, Xinan , HE, Ting , QI, Feifei , HUANG, Ru
IPC分类号： C07K16/44 , G01N33/68 , G01N33/577 , C07K19/00 , C07K1/14
摘要： Disclosed is an antibody that specifically binds to a Strep-Tag II tag, and further disclosed are an amino acid sequence of the antibody of the present invention, a cloning or expression vector, a host cell, and a method for expressing or separating the antibody, and also disclosed is a composition comprising the antibody of the present invention. Also disclosed is a method for detecting or purifying a biological sample expressing the Strep-Tag II Tag by means of using the antibody of the present invention.
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公开(公告)号：EP4273168A1
公开(公告)日：2023-11-08
申请号：EP21914601.6
申请日：2021-12-30
发明人： LU, Xinan , HE, Ting , QI, Feifei , DING, Yanping , LIU, Guanghua , HU, Xuelian , XU, Wenping
IPC分类号： C07K16/28 , C07K19/00 , C12N15/13 , C12N15/62 , C12N5/10 , A61K39/00 , A61K35/17 , A61P35/00 , A61P35/02 , A61P37/02 , A61P31/04 , A61P31/12
摘要： Disclosed is an antibody that specifically binds to BCMA. The antibody comprises a heavy chain variable domain VH, a light chain variable domain VL, and a chimeric antigen receptor that contains the sequence thereof. Further disclosed are the amino acid sequence, a vector, a host cell, and a composition of the antibody or the chimeric antigen receptor of the present invention. Also disclosed is a use of the antibody or the chimeric antigen receptor in the preparation of a drug for the prevention or treatment of diseases.
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公开(公告)号：EP4257677A1
公开(公告)日：2023-10-11
申请号：EP21899849.0
申请日：2021-11-16
发明人： QI, Feifei , LU, Xin'an , HE, Ting , DENG, Cuiyun
IPC分类号： C12N5/10 , C12N15/867 , C12N7/01 , C12R1/91
摘要： Provided are a stable lentivirus packaging cell line and a preparation method therefor. The stable lentivirus packaging cell line contains a packaging plasmid group consisting of a pPuro.coTetR plasmid, a pVSVG plasmid, and a pGagPol-RRE-NES-cINT plasmid, wherein the pPuro.coTetR plasmid contains a CoTetR gene, the pVSVG plasmid contains a VSVG gene, and the pGagPol-RRE-NES-cINT plasmid contains GagPol and Rev genes. The stable lentivirus packaging cell line is relatively stable in terms of passage, virus production, and a genetic gene copy number, and the lentivirus produced by using the stable lentivirus packaging cell line has a high titer and a low impurity content.
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公开(公告)号：EP4104850A1
公开(公告)日：2022-12-21
申请号：EP21752943.7
申请日：2021-02-09
发明人： QI, Feifei , HE, Ting , LU, Xinan , DING, Yanping , XIONG, Fuyin , LIANG, Mengmeng
摘要： The present invention relates to the optimization of a chimeric antigen receptor, in particular, the modification of an intracellular signaling domain.
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公开(公告)号：EP4104840A1
公开(公告)日：2022-12-21
申请号：EP21753522.8
申请日：2021-02-09
发明人： LU, Xinan , HE, Ting , QI, Feifei , DING, Yanping , XIONG, Fuyin , LIANG, Mengmeng
IPC分类号： A61K35/14 , A61P35/00 , C07K16/28 , C07K14/705
摘要： The present invention relates to the optimization of a chimeric antigen receptor, in particular, the modification of an intracellular co-stimulatory domain.
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