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1.发明授权
公开(公告)号：EP2246357B1
公开(公告)日：2012-08-29
申请号：EP10158896.0
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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公开(公告)号：EP2246358A1
公开(公告)日：2010-11-03
申请号：EP10158897.8
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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3.发明授权Oligonucleotides against HIV infection and its application in the prevention and treatment of acquired immune deficiency syndrome 有权抗HIV感染的寡核苷酸及其在预防和治疗获得性免疫缺陷综合征中的应用
公开(公告)号：EP2243786B1
公开(公告)日：2012-08-22
申请号：EP10158895.2
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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4.发明公开Oligonucleotides against HIV infection and its application in the prevention and treatment of acquired immune deficiency syndrome 有权抗HIV感染的寡核苷酸及其在预防和治疗获得性免疫缺陷综合征中的应用
公开(公告)号：EP2266995A1
公开(公告)日：2010-12-29
申请号：EP10158898.6
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
摘要翻译： 本发明提供了一套针对HIV感染的核苷酸及其用于治疗和预防AIDS的应用。 核苷酸的序列显示在序列表中。 本发明优于以下类似技术：通过比较所有已发表的HIV基因组序列，得到高度保守的RNA序列。 源自序列的双链RNA序列可以有效地抑制HIV靶基因的表达。 HIV基因表达也可以通过携带含有编码RNA序列的DNA序列的重组质粒的细胞中转录的双链发夹样RNA来抑制。 此外，HIV基因表达可以通过在与由重组腺病毒相关病毒编码的RNA序列相对应的细胞转录的双链RNA中被敲低。
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5.发明授权
公开(公告)号：EP2246358B1
公开(公告)日：2012-07-25
申请号：EP10158897.8
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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公开(公告)号：EP2243786A1
公开(公告)日：2010-10-27
申请号：EP10158895.2
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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公开(公告)号：EP2266995B1
公开(公告)日：2012-09-19
申请号：EP10158898.6
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
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8.发明公开
公开(公告)号：EP2246357A1
公开(公告)日：2010-11-03
申请号：EP10158896.0
申请日：2003-12-16
发明人： Zhou, Zhiwen , Feng, Yuxia , Zuo, Conglin , Li, Yuejuan
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , Y02A50/395
摘要： The invention provides a set of nucleotides against HIV infection and their application for treatment and prevention of AIDS. The sequences of the nucleotides were shown in the sequences table. The invention was superior to the similar technology as following: High conserved RNA sequences were obtained by compare all the published HIV genome sequences. Double strand RNA sequences derived from the sequences can effectively inhibit the expression of target HIV gene. HIV gene expression can also be inhibited by double strand hairpin-like RNA transcribed in the cells harboring recombinant plasmid which contain the DNA sequences encoding the RNA sequences. Further, HIV gene expression can be knocked down by in cell transcribed double strand RNA corresponding to the RNA sequences encoded by recombinant adenovirus associated virus.
摘要翻译： 本发明提供了一组抗HIV感染及其治疗和预防艾滋病的应用核苷酸。 核苷酸的序列在序列表2所示。 本发明如下什么优于同类技术：高保守的RNA序列进行比较所有公布的HIV基因组序列获得。 从序列的双海滩RNA序列可有效抑制靶HIV基因的表达。 HIV基因表达因此可以通过在包含编码RNA序列的DNA序列细胞携带重组质粒转录双海滩发夹样RNA被抑制。 此外，HIV基因表达可以通过在细胞中转录双海滩RNA对应于由重组腺病毒相关病毒编码的RNA序列撞倒。
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