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    Polypeptide fragments of hepatitis E virus, vaccine composition comprising said fragments and diagnostic kits
    4.
    发明公开
    Polypeptide fragments of hepatitis E virus, vaccine composition comprising said fragments and diagnostic kits 审中-公开
    多发性肝炎病毒，多发性肝炎病毒，多发性肝炎病毒

    公开(公告)号：EP2298793A2

    公开(公告)日：2011-03-23

    申请号：EP10183446.3

    申请日：2001-09-30

    申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

    发明人： Xia, Ningshao ,  Zhang, Jun ,  Li, Shaowei ,  Ge, Shengxiang ,  Gu, Ying ,  He, Zhigiang

    IPC分类号： C07K14/08 ,  C12N15/51 ,  C12N5/10 ,  A61K39/29 ,  G01N33/569 ,  G01N33/576 ,  C12Q1/70

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6075 ,  C07K16/10 ,  C07K2319/00 ,  C12N2760/16022 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28171 ,  G01N33/576

    摘要： The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.

    摘要翻译： 本发明涉及多肽，其包含戊型肝炎病毒ORF 2的SEQ ID No.1所示的氨基酸序列或其片段，其为n-聚合多肽形式，其中n为 1-180; 涉及由本发明的多肽和来自流感病毒的血凝素抗原的保守片段组成的嵌合蛋白; 涉及与来自戊型肝炎病毒ORF3或其免疫原性片段的含有多肽的表位结合的本发明的多肽; 涉及包含编码上述多肽的DNA分子和能够表达本发明的多肽的所述重组表达载体转化的宿主细胞的重组表达载体。 本发明还涉及一种抗艾滋病毒病毒的疫苗组合物，其包含上述多肽或用于戊型肝炎病毒感染的诊断试剂盒，其包含上述多肽，其包括IgG，IgM或用于戊型肝炎的总体抗体诊断试剂盒 病毒，以及使用疫苗组合物和诊断试剂盒进行戊型肝炎病毒感染的预防，诊断和/或治疗。