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1.发明公开VOLTAGE DEPENDENT ANION CHANNEL (VDAC1) COMPOSITIONS AND METHODS OF USE THEREOF FOR REGULATING APOPTOSIS 有权电压依赖性阴离子通道中的用途调控凋亡构成（VDAC1）AND METHOD
公开(公告)号：EP1856145A2
公开(公告)日：2007-11-21
申请号：EP06711293.8
申请日：2006-03-09
IPC分类号： C07K14/435 , A61K38/00 , C07K14/47 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K14/4747
摘要： The present invention relates generally to the mitochondrial protein, voltage- dependent anion channel (VDAC)5 polynucleotides encoding same and variants thereof, as well as peptide fragments, peptide derivatives and analogs. In particular, the present invention is directed to VDACl and specific amino acid and polynucleotide sequences thereof useful in inducing or regulating apoptosis and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with aberrant apoptosis.
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2.发明公开
公开(公告)号：EP1722818A2
公开(公告)日：2006-11-22
申请号：EP05703240.1
申请日：2005-02-17
IPC分类号： A61K47/00
CPC分类号： C07K14/4728 , A61K38/00 , A61K41/0042 , A61K51/02 , G01N2333/4727
摘要： The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.
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公开(公告)号：EP2742358A1
公开(公告)日：2014-06-18
申请号：EP12830782.4
申请日：2012-09-06
申请人： Ben-Gurion University of The Negev Research and Development Authority , The National Institute for Biotechnology in the Negev Ltd.
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57407 , G01N33/57426
摘要： The present invention relates to methods and kits for the detection of cancer and for pre-cancer screening based on the expression of genes associated with altered metabolism and apoptosis in cancerous cells, particularly the expression of a mitochondrial antiviral-signaling (MAVS) or a voltage-dependent anion channel 1 (VDAC1) protein or mRNA in combination with additional genes associated with cell metabolism and/or apoptosis.
摘要翻译： 本发明涉及基于与癌细胞中改变的代谢和凋亡有关的基因的表达，特别是线粒体抗病毒信号传导（MAVS）的表达或电压 依赖性阴离子通道1（VDAC1）蛋白或mRNA与其他与细胞代谢和/或凋亡相关的基因组合。
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4.发明授权VOLTAGE DEPENDENT ANION CHANNEL (VDAC1) COMPOSITIONS AND METHODS OF USE THEREOF FOR REGULATING APOPTOSIS 有权电压依赖性阴离子通道中的用途调控凋亡构成（VDAC1）AND METHOD
公开(公告)号：EP1856145B1
公开(公告)日：2013-12-04
申请号：EP06711293.8
申请日：2006-03-09
IPC分类号： C07K14/435 , A61K38/00 , C07K14/47 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K14/4747
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公开(公告)号：EP1934348A1
公开(公告)日：2008-06-25
申请号：EP06796164.9
申请日：2006-10-15
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates generally to the down regulation of mitochondrial protein, voltage-dependent anion channel (VDAC1), expression by RNAi or antisense therapy. In particular, the present invention is directed to VDAC1 silencing molecules useful in regulating cell proliferation and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with aberrant cell proliferation.
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公开(公告)号：EP1934348B1
公开(公告)日：2018-05-02
申请号：EP06796164.9
申请日：2006-10-15
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates generally to the down regulation of mitochondrial protein, voltage-dependent anion channel (VDAC1), expression by RNAi or antisense therapy. In particular, the present invention is directed to VDAC1 silencing molecules useful in regulating cell proliferation and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with aberrant cell proliferation.
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