公开(公告)号：EP1003904B1

公开(公告)日：2007-07-11

申请号：EP98923786.2

申请日：1998-05-22

申请人： BioArray Solutions Ltd. ,  Rutgers, The State University of New Jersey

发明人： SEUL, Michael ,  EBRIGHT, Richard, H.

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N21/00 ,  G01N21/76 ,  G01N33/53 ,  G01N33/533 ,  G01N33/543 ,  G01N33/566 ,  C07B61/00 ,  B01J19/00 ,  G01N33/68

CPC分类号： C40B20/04 ,  B01J19/0046 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C40B50/04 ,  C40B50/16 ,  C40B70/00 ,  G01N21/29 ,  G01N21/64 ,  G01N21/6458 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/6845 ,  G01N2021/1765

摘要： A method and apparatus for the physico-chemical encoding of a collection of beaded resin ("beads") to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.

公开(公告)号：EP3102193A1

公开(公告)日：2016-12-14

申请号：EP15745890.2

申请日：2015-02-06

申请人： Rutgers, The State University of New Jersey

发明人： EBRIGHT, Richard, H. ,  EBRIGHT, Yon, W. ,  MANDAL, Soma ,  WILDE, Richard ,  LI, Shengjian

IPC分类号： A61K31/16 ,  A01N37/18 ,  A01N37/46 ,  A61P31/04

CPC分类号： C07C233/88 ,  A01N37/22 ,  A01N37/24 ,  A01N43/10 ,  A01N43/30 ,  A01N43/32 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/48 ,  A01N43/50 ,  A01N43/52 ,  A01N43/56 ,  A01N43/60 ,  A01N43/62 ,  A01N43/647 ,  A01N43/653 ,  A01N43/713 ,  A01N43/78 ,  A01N43/84 ,  A01N43/90 ,  A61K31/167 ,  A61K31/341 ,  A61K31/4402 ,  A61K31/4409 ,  C07C237/20 ,  C07C2602/08 ,  C07C2602/10 ,  C07D207/14 ,  C07D209/08 ,  C07D209/40 ,  C07D209/42 ,  C07D211/58 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/38 ,  C07D215/40 ,  C07D217/22 ,  C07D231/56 ,  C07D235/06 ,  C07D237/30 ,  C07D241/04 ,  C07D249/06 ,  C07D249/08 ,  C07D249/18 ,  C07D257/04 ,  C07D265/30 ,  C07D277/62 ,  C07D295/135 ,  C07D295/155 ,  C07D295/185 ,  C07D295/205 ,  C07D307/82 ,  C07D317/66 ,  C07D319/18 ,  C07D333/38 ,  C07D333/54 ,  C07D333/66 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04

摘要： The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.

摘要翻译： 本发明提供具有作为细菌RNA聚合酶抑制剂和抗菌剂的活性的化合物，以及包含这些化合物的组合物及其使用方法。 具体地，公开了对结核分枝杆菌RNA聚合酶具有抑制活性的苯丙氨酸酰胺和酪氨酰胺化合物。 公开了这些化合物在哺乳动物中用于治疗或预防结核分枝杆菌感染的用途。

公开(公告)号：EP1003904A1

公开(公告)日：2000-05-31

申请号：EP98923786.2

申请日：1998-05-22

申请人： Bioarray Solutions, LLC ,  Rutgers, The State University of New Jersey

发明人： SEUL, Michael ,  EBRIGHT, Richard, H.

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N21/00 ,  G01N21/76 ,  G01N33/53 ,  G01N33/533 ,  G01N33/543 ,  G01N33/566

CPC分类号： C40B20/04 ,  B01J19/0046 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C40B50/04 ,  C40B50/16 ,  C40B70/00 ,  G01N21/29 ,  G01N21/64 ,  G01N21/6458 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/6845 ,  G01N2021/1765

摘要： A method and apparatus for the physico-chemical encoding of a collection of beaded resin ("beads") to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.

公开(公告)号：EP1506402A2

公开(公告)日：2005-02-16

申请号：EP02807321.1

申请日：2002-11-12

申请人： Rutgers, The State University of New Jersey

发明人： EBRIGHT, Richard, H. ,  EBRIGHT, Yon, W.

IPC分类号： G01N33/532 ,  C07D209/14

CPC分类号： C07D209/14

摘要： A probe for labeling a target material is provided including two transition-metal chelates and detectable group. The probe has the general structural formula (I) wherein: (a) Y and Y' are each a transition metal, (b) R1 and R1 are each independently CH(COO-), CH(COOH), or absent; (c)R2 and R2 are linkers each having a length of from about 3.0 to about 20 Å; and (d) X is a detectable group. The linkers may be linear or branched, may contain aromatic moeties, and may optionally be further substituted. Methods of use of the probe in detecting and analyzing target materials of interest also are provided.