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公开(公告)号：EP4405050A1
公开(公告)日：2024-07-31
申请号：EP22782722.7
申请日：2022-09-21
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2.发明公开
公开(公告)号：EP3658587A2
公开(公告)日：2020-06-03
申请号：EP18753084.5
申请日：2018-07-26
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3.发明公开USE OF ANTIBODIES AGAINST ICAM-1 IN THE TREATMENT OF PATIENTS WITH RELAPSED CANCER 审中-公开抗体与ICAM-1使用肿瘤患者复发治疗
公开(公告)号：EP2593481A1
公开(公告)日：2013-05-22
申请号：EP11749359.3
申请日：2011-07-13
发明人： HANSSON, Markus , FRENDEUS, Björn
IPC分类号： C07K16/28
CPC分类号： C07K16/2821 , A61K9/0019 , A61K9/20 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： There is provided antibodies or antigen-binding fragments thereof with binding specificity for ICAM-1, for use in the treatment of cancer in patients who have previously been treated for cancer and either not responded to said treatment or have previously responded to said treatment and subsequently relapsed.
摘要翻译： 本发明提供抗体或其抗原结合片段具有结合特异性为ICAM-1，用于在患者中治疗癌症中的用途谁先前已经治疗癌症和要么没有响应所述治疗或之前响应所述治疗，随后其 复发。
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4.发明公开Peptide-based passive immunization therapy for treatment of atherosclerosis 审中-公开基于肽的被动免疫疗法治疗动脉粥样硬化
公开(公告)号：EP2361633A1
公开(公告)日：2011-08-31
申请号：EP10075394.6
申请日：2003-10-06
IPC分类号： A61K39/00
CPC分类号： C07K14/775 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical of prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.
摘要翻译： 本发明涉及用于治疗或预防动脉粥样硬化的被动免疫，其使用针对至少一种载脂蛋白B的氧化片段的分离的人抗体在制备用于通过被动免疫来预防性治疗动脉粥样硬化的药物组合物中的用途，以及 制备此类抗体的方法，以及使用这种抗体治疗哺乳动物，优选人的方法以提供被动免疫。
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公开(公告)号：EP1545609B1
公开(公告)日：2011-02-16
申请号：EP03748843.4
申请日：2003-10-06
IPC分类号： A61K39/395 , C07K16/18 , A61P9/10
CPC分类号： C07K14/775 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical of prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.
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公开(公告)号：EP1960432A2
公开(公告)日：2008-08-27
申请号：EP06829616.9
申请日：2006-12-08
发明人： FRENDÉUS, Björn , CARLSSON, Roland
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.
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公开(公告)号：EP1088069B1
公开(公告)日：2005-05-11
申请号：EP99927981.3
申请日：1999-06-11
发明人： HOLMGREN, Lars , TROYANOVSKY, Boris
摘要： The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in screening methods, wherein novel substances are created exhibiting the same advantageous anti-angiogenic properties as angiostatin.
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公开(公告)号：EP0850299A1
公开(公告)日：1998-07-01
申请号：EP96930279.0
申请日：1996-09-13
CPC分类号： C40B40/02 , C07K14/005 , C07K14/245 , C07K2319/00 , C12N15/1037 , C12N15/1055 , C12N15/70 , C12N2710/16122 , C12N2740/16222
摘要： A method for selecting nucleic acid sequences encoding ligand and receptor molecules capable of specific binding to each other is disclosed in which nucleic acid encoding ligand or receptor molecules is expressed in a host microorganism in combination with a surface molecule, such as E. coli pili, so that the ligand or receptor are displayed on the surface of the host microorganism. A replicable genetic unit, such as a filamentous bacteriophage, is used to display candidate binding partners to the ligand or receptor, with the binding of the ligand or receptor to the candidate binding partner mediating the transfer of nucleic acid from the replicable genetic unit to the microorganism. The method can be highly selective as the host microorganism is modified so that it does not display the surface molecule other than as a fusion with the ligand or receptor molecule. The method is rapid and simple and opens up new applications based on the detection of ligand and receptors where both are unknown.
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公开(公告)号：EP3999186A1
公开(公告)日：2022-05-25
申请号：EP20740627.3
申请日：2020-07-17
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公开(公告)号：EP2758532B1
公开(公告)日：2018-07-11
申请号：EP12766050.4
申请日：2012-09-20
发明人： FRENDÉUS, Björn , MATTSSON, Jenny
CPC分类号： G01N33/566 , C12N15/1037 , G01N33/6845 , G01N33/6857 , G01N2500/00
摘要： The present invention relates to improved screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands.
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