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公开(公告)号：EP2925348A1
公开(公告)日：2015-10-07
申请号：EP13796006.8
申请日：2013-11-26
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/55561 , A61K2039/572 , A61K2039/605 , A61K2039/627
摘要： The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.
摘要翻译： 本发明涉及针对肿瘤抗原，特别是共享的肿瘤抗原的个体表达模式和个体肿瘤突变的患者特异性肿瘤治疗。 一方面，本发明涉及一种用于预防或治疗患者的癌症的方法，包括以下步骤：（i）诱导针对患者中一种或多种肿瘤抗原的第一免疫应答，和（ii）诱导第二免疫 对患者中一种或多种肿瘤抗原的反应，其中所述第二免疫应答对存在于患者的癌细胞中的癌症特异性体细胞突变是特异性的。
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公开(公告)号：EP3417874A1
公开(公告)日：2018-12-26
申请号：EP18172228.1
申请日：2013-11-26
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/55561 , A61K2039/572 , A61K2039/605 , A61K2039/627
摘要： The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.
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公开(公告)号：EP2925348B1
公开(公告)日：2019-03-06
申请号：EP13796006.8
申请日：2013-11-26
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/00
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公开(公告)号：EP3209696A1
公开(公告)日：2017-08-30
申请号：EP15781663.8
申请日：2015-10-19
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , BENDER, Christian , VORMBROCK, Kirsten , BAREA ROLDAN, Diana , HUBICH, Stefanie , HARTMANN, Christoph
IPC分类号： C07K16/30 , C12Q1/00 , G01N33/574 , A61K35/00
CPC分类号： G01N33/57484 , A61K35/17 , A61K38/03 , A61K48/005 , C07K14/4747 , C07K16/30 , C12Q1/6886 , G01N33/5011 , G01N33/57407 , G01N2800/52
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues,in particular tumors of the central nervous system (CNS) such as glioma, in particular glioblastoma and which represent targets for therapy or diagnosis of tumor diseases in a subject.
摘要翻译： 本发明涉及鉴定肿瘤组织特有的核酸和氨基酸序列，特别是中枢神经系统（CNS）的肿瘤如神经胶质瘤，特别是成胶质细胞瘤，并且其代表肿瘤疾病的治疗或诊断的靶标 在一个主题。
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公开(公告)号：EP3027203B1
公开(公告)日：2020-07-29
申请号：EP14747589.1
申请日：2014-07-30
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , VORMBROCK, Kirsten , BENDER, Christian , OEHM, Petra , HARTMANN, Christoph , HUBICH, Stefanie , BUKUR, Thomas , LITZENBERGER, Thorsten
IPC分类号： A61K39/00 , A61K31/7105 , C07K14/47 , C12Q1/68 , G01N33/574
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公开(公告)号：EP3027203A1
公开(公告)日：2016-06-08
申请号：EP14747589.1
申请日：2014-07-30
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , VORMBROCK, Kirsten , BENDER, Christian , SIMON, Petra , HARTMANN, Christoph , HUBICH, Stefanie , BUKUR, Thomas , LITZENBERGER, Thorsten
IPC分类号： A61K39/00 , A61K31/7105 , C07K14/47 , C12Q1/68 , G01N33/574
摘要： The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for cancer treatment involving a specific set of tumor antigens.
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公开(公告)号：EP3922648A1
公开(公告)日：2021-12-15
申请号：EP21171648.5
申请日：2015-10-19
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , BENDER, Christian , VORMBROCK, Kirsten , BAREA ROLDAN, Diana , HUBICH, Stefanie , HARTMANN, Christoph
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues, in particular tumors of the central nervous system (CNS) such as glioma, in particular glioblastoma and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：EP3777882A1
公开(公告)日：2021-02-17
申请号：EP20186963.3
申请日：2014-07-30
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , PARET, Claudia , VORMBROCK, Kirsten , BENDER, Christian , OEHM, Petra , HARTMANN, Christoph , HUBICH, Stefanie , BUKUR, Thomas , LITZENBERGER, Thorsten
IPC分类号： A61K39/00 , A61K31/7105 , C07K14/47 , C12Q1/68 , G01N33/574 , C12Q1/6886
摘要： The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for cancer treatment involving a specific set of tumor antigens.
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