公开(公告)号：EP3636764A1

公开(公告)日：2020-04-15

申请号：EP19198322.0

申请日：2016-10-05

申请人： BioNTech RNA Pharmaceuticals GmbH ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： ORLANDINI VON NIESSEN, Alexandra ,  FESSER, Stephanie ,  VALLAZZA, Britta ,  BEISSERT, Tim ,  KUHN, Andreas ,  SAHIN, Ugur ,  POLEGANOV, Marco Alexander

IPC分类号： C12N15/67

摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro -transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

公开(公告)号：EP3337902A2

公开(公告)日：2018-06-27

申请号：EP16778784.5

申请日：2016-10-05

申请人： BioNTech RNA Pharmaceuticals GmbH ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： ORLANDINI VON NIESSEN, Alexandra ,  FESSER, Stephanie ,  VALLAZZA, Britta ,  BEISSERT, Tim ,  KUHN, Andreas ,  SAHIN, Ugur ,  POLEGANOV, Marco Alexander

IPC分类号： C12N15/67

CPC分类号： C12N15/67

摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.