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公开(公告)号：EP3681993A1
公开(公告)日：2020-07-22
申请号：EP18769157.1
申请日：2018-09-11
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公开(公告)号：EP3681901A1
公开(公告)日：2020-07-22
申请号：EP18769331.2
申请日：2018-09-11
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/005 , C12N5/074
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公开(公告)号：EP3636764A1
公开(公告)日：2020-04-15
申请号：EP19198322.0
申请日：2016-10-05
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： ORLANDINI VON NIESSEN, Alexandra , FESSER, Stephanie , VALLAZZA, Britta , BEISSERT, Tim , KUHN, Andreas , SAHIN, Ugur , POLEGANOV, Marco Alexander
IPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro -transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
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公开(公告)号：EP3337902A2
公开(公告)日：2018-06-27
申请号：EP16778784.5
申请日：2016-10-05
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： ORLANDINI VON NIESSEN, Alexandra , FESSER, Stephanie , VALLAZZA, Britta , BEISSERT, Tim , KUHN, Andreas , SAHIN, Ugur , POLEGANOV, Marco Alexander
IPC分类号： C12N15/67
CPC分类号： C12N15/67
摘要： The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
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公开(公告)号：EP4368702A2
公开(公告)日：2024-05-15
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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公开(公告)号：EP4368702A3
公开(公告)日：2024-08-14
申请号：EP24165309.6
申请日：2018-09-11
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K14/005 , C12N5/074
CPC分类号： C07K14/005 , C12N5/0696 , C12N2501/0020130101 , C12N2760/1202220130101 , C12N2501/60220130101 , C12N2501/60320130101 , C12N2501/60420130101 , C12N2501/60520130101 , C12N2501/60620130101 , C12N2501/60820130101 , C12N2501/6520130101 , C12N2510/0020130101 , Y02A50/30
摘要： The present invention describes a virus-derived factor which when provided to cells, e.g., by transfecting the cells with RNA encoding the virus-derived factor, enhances expression of RNA encoding a peptide or protein in the cells. In particular, the virus-derived factor enhances survival of cells, in particular when transfected repetitively with RNA, and reduces an IFN response of cells to transfected RNA. Accordingly, the present invention provides methods and means for enhancing expression of RNA in cells. The cells are preferably transfected with the RNA.
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