专利检索 ap:("Bioferma Murcia, S.A.") AND inv:"SANCHEZ FERRER, Alvaro" 第 1 页

1.

发明公开
SIMPLE ENZYMATIC PROCESS FOR PREPARING CEFAZOLIN 审中-公开
标题翻译： SIMPLE酶解过程用于生产CEFALOZOLIN

公开(公告)号：EP1556500A1

公开(公告)日：2005-07-27

申请号：EP03773688.1

申请日：2003-10-30

申请人： Bioferma Murcia, S.A.

发明人： GARCIA CARMONA, Francisco , SANCHEZ FERRER, Alvaro

IPC分类号： C12P35/04 , C12N9/84 , C07D501/36

CPC分类号： C12Y305/01011 , C12P35/04

摘要： A process for preparing the 7-(1-H-tetrazol-1-yl) acetamide-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid or cefazolin, comprising catalysing the acylation of the amino β-lactam, the 7-amino-3-[5methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-3-cephem-4-carboxylic acid, of the formula with an activated acylating agent derived from acetic acid in the presence of a biocatalyst comprising penicillin amidase, and a product of the formula I obtainable by the foregoing process according to claims.