利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

35 条记录 (耗时 0.019 秒)

    Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
    1.
    发明公开
    Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof 审中-公开
    多肽多聚核苷酸代谢产物Leseraster aus肺炎链球菌和Verwendungen davon

    公开(公告)号：EP2277897A1

    公开(公告)日：2011-01-26

    申请号：EP10181319.4

    申请日：2002-04-12

    申请人： Wyeth Holdings Corporation

    发明人： Zagursky, Robert John ,  Masi, Amy Wadhams ,  Green, Bruce Arthur ,  Chakravarti, Deb Narayan ,  Russel, David Parrish ,  Wooters, Joseph Lawrence

    IPC分类号： C07K14/315 ,  C12N15/00 ,  C12N1/21 ,  C12Q1/68 ,  C12Q1/30 ,  C07K16/12 ,  C12N9/88

    CPC分类号： C12N9/88 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/3156 ,  C07K2319/00 ,  C12Q1/689 ,  C12Y305/01011

    摘要： The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by Streptococcus pneumoniae. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by Streptococcus pneumoniae.

    摘要翻译： 本发明涉及包含在肺炎链球菌的基因组核苷酸序列中的新鉴定的开放阅读框，其中开放阅读框编码表面定位于肺炎链球菌上的多肽。 因此，本发明涉及编码由肺炎链球菌开放阅读框编码的多肽抗原，多肽，优选抗原性多肽的肺炎链球菌开放阅读框，包含开放阅读框序列的载体和用这些载体转化的细胞或动物。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎链球菌感染的试剂盒。 本发明最终涉及用于预防和/或治疗细菌感染，特别是肺炎链球菌感染的药物组合物，特别是免疫原性组合物。 在具体实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的全身性疾病。 在其它实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的非全身性疾病，特别是中耳炎。

    NOVEL STREPTOCOCCUS PNEUMONIAE OPEN READING FRAMES ENCODING POLYPEPTIDE ANTIGENS AND USES THEREOF
    3.
    发明公开
    NOVEL STREPTOCOCCUS PNEUMONIAE OPEN READING FRAMES ENCODING POLYPEPTIDE ANTIGENS AND USES THEREOF 审中-公开
    多肽抗原编码肺炎链球菌的开放阅读框和其用途

    公开(公告)号：EP1572868A2

    公开(公告)日：2005-09-14

    申请号：EP02728746.5

    申请日：2002-04-12

    申请人： Wyeth Holdings Corporation

    发明人： ZAGURSKY, Robert, John ,  MASI, Amy, Wadhams ,  GREEN, Bruce, Arthur ,  CHAKRAVARTI, Deb, Narayan ,  RUSSELL, David, Parrish ,  WOOTERS, Joseph, Lawrence

    IPC分类号： C12N1/00

    CPC分类号： C12N9/88 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/3156 ,  C07K2319/00 ,  C12Q1/689 ,  C12Y305/01011

    摘要： The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by Streptococcus pneumoniae. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by Streptococcus pneumoniae.

    STREPTOCOCCUS PNEUMONIAE OPEN READING FRAMES ENCODING POLYPEPTIDE ANTIGENS AND USES THEREOF
    7.
    发明公开
    STREPTOCOCCUS PNEUMONIAE OPEN READING FRAMES ENCODING POLYPEPTIDE ANTIGENS AND USES THEREOF 审中-公开
    多萜类化合物多萜类化合物

    公开(公告)号：EP2261241A1

    公开(公告)日：2010-12-15

    申请号：EP10181218.8

    申请日：2002-04-12

    申请人： Wyeth Holdings Corporation

    发明人： Zagursky, Robert John ,  Masi, Amy Wadhams ,  Green, Bruce Arthur ,  Chakravarti, Deb Narayan ,  Russel, David Parrish ,  Wooters, Joseph Lawrence

    IPC分类号： C07K14/315 ,  C12N15/00 ,  C12N1/21 ,  C12Q1/68 ,  C12Q1/30 ,  C07K16/12

    CPC分类号： C12N9/88 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/3156 ,  C07K2319/00 ,  C12Q1/689 ,  C12Y305/01011

    摘要： The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae. In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by Streptococcus pneumoniae. In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by Streptococcus pneumoniae.

    摘要翻译： 本发明涉及包含在肺炎链球菌的基因组核苷酸序列中的新鉴定的开放阅读框，其中开放阅读框编码表面定位于肺炎链球菌上的多肽。 因此，本发明涉及编码由肺炎链球菌开放阅读框编码的多肽抗原，多肽，优选抗原性多肽的肺炎链球菌开放阅读框，包含开放阅读框序列的载体和用这些载体转化的细胞或动物。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎链球菌感染的试剂盒。 本发明最终涉及用于预防和/或治疗细菌感染，特别是肺炎链球菌感染的药物组合物，特别是免疫原性组合物。 在具体实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的全身性疾病。 在其它实施方案中，免疫原性组合物用于治疗或预防由肺炎链球菌引起或加重的非全身性疾病，特别是中耳炎。

    Penicillin V amidohydrolase gene from fusarium oxysporum
    9.
    发明公开
    Penicillin V amidohydrolase gene from fusarium oxysporum 失效
    青霉素V酰氨基水解酶产生于尖孢镰孢

    公开(公告)号：EP0718402A2

    公开(公告)日：1996-06-26

    申请号：EP95120437.9

    申请日：1995-12-22

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Chiang, Shu-Jen ,  Burnett, William V. Jr. ,  Tonzi, Sean M.

    IPC分类号： C12N15/55 ,  C12N9/84 ,  C12N15/80 ,  C12N1/15 ,  C12N1/21

    CPC分类号： C12Y104/03003 ,  C12N9/0024 ,  C12N9/84 ,  C12N15/80 ,  C12Y305/01011

    摘要： The present invention relates to nucleic acids coding for penicillin V amidohydrolase (PVA) from Fusarium oxysporum as well as expression vectors, host cells and a method for production of PVA.

    摘要翻译： 以下序列是新的：（a）编码说明书中给出的507或532个氨基酸序列的PVA DNA或cDNA（I）序列; （b）说明书中给出的240bp的PVA基因启动子（II）; （c）23-33bp长的PVA基因片段和编码的肽; （d）与（a）的序列互补的序列; （e）能够在严格条件下与（d）杂交的序列; （f）简并寡核苷酸探针和用于构建探针的序列; 和（g）用于载体构建的致突变寡核苷酸。 还要求的是（1）由（I）编码的多肽; （2）包含（I）和启动子（II）的表达载体; （3）（2）的宿主细胞contg.an表达载体; （4）六个分离的主要PVA片段（A，B1，B2，C，D和E）的N-末端肽和（5）大肠杆菌ATCC 69720,69721和69772的生物学纯样品。