公开(公告)号：EP1596656A2

公开(公告)日：2005-11-23

申请号：EP04710613.3

申请日：2004-02-12

申请人： Biogen Idec MA Inc.

发明人： LEE, Wen-Cherng ,  SUN, Lihong ,  SHAN, Feng ,  CHUAQUI, Claudio ,  CORNEBISE, Mark ,  PONTZ, Timothy, W. ,  CARTER, Marybeth ,  SINGH, Juswinder ,  BORIACK-SJODIN, Paula, Ann ,  LING, Leona ,  PETTER, Russell, C.

IPC分类号： A01N43/58 ,  A01N43/60 ,  A01N43/42 ,  A01N43/40 ,  A61K31/54 ,  A61K31/501 ,  A61K31/495 ,  A61K31/497 ,  A61K31/47 ,  A61K31/50 ,  A61K31/4965 ,  A61K31/44

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).