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公开(公告)号：EP1786802A1
公开(公告)日：2007-05-23
申请号：EP05789340.6
申请日：2005-08-24
申请人： Biogen Idec MA, Inc.
发明人： LEE, Wen-Cherng , SUN, Lihong , CHUAQUI, Claudio , SINGH, Juswinder , SHAN, Feng
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D405/14 , C07D403/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14
摘要： Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of the general formula (I) and uses thereof.
摘要翻译： 式（I）化合物对Alk 5和/或Alk 4具有意想不到的高亲和力，并且可用作其拮抗剂用于预防和/或治疗许多疾病，包括纤维化疾病。 本发明的特征在于通式（I）的化合物及其用途。
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公开(公告)号：EP1265606B1
公开(公告)日：2006-10-25
申请号：EP00959232.0
申请日：2000-08-14
申请人： Biogen Idec MA Inc.
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/445 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D207/16 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07K5/02 , C07K5/06
CPC分类号： C07D401/06 , A61K38/00 , C07D205/04 , C07D207/16 , C07D207/48 , C07D209/42 , C07D211/32 , C07D265/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07K5/0215 , C07K5/06165 , C07K5/06191
摘要： A cell adhesion inhibitor of the general formula: R?3-L-L'-R1¿ is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.
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公开(公告)号：EP1596656A2
公开(公告)日：2005-11-23
申请号：EP04710613.3
申请日：2004-02-12
申请人： Biogen Idec MA Inc.
发明人： LEE, Wen-Cherng , SUN, Lihong , SHAN, Feng , CHUAQUI, Claudio , CORNEBISE, Mark , PONTZ, Timothy, W. , CARTER, Marybeth , SINGH, Juswinder , BORIACK-SJODIN, Paula, Ann , LING, Leona , PETTER, Russell, C.
IPC分类号： A01N43/58 , A01N43/60 , A01N43/42 , A01N43/40 , A61K31/54 , A61K31/501 , A61K31/495 , A61K31/497 , A61K31/47 , A61K31/50 , A61K31/4965 , A61K31/44
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
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公开(公告)号：EP1546112A2
公开(公告)日：2005-06-29
申请号：EP03752004.6
申请日：2003-09-05
申请人： Biogen Idec MA Inc.
发明人： LEE, Wen-Cherng , CARTER, Mary, Beth , SUN, Lihong , CHUAQUI, Claudio , SINGH, Juswinder , BORIACK-SJODIN, Paula , CHOI, Michael, J.
IPC分类号： C07D237/00 , C07D239/00 , A01N43/00 , A61K31/535
CPC分类号： C07D471/04 , C07D471/02 , C07D487/04
摘要： Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:
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公开(公告)号：EP1971594A2
公开(公告)日：2008-09-24
申请号：EP06847481.6
申请日：2006-11-21
申请人： Biogen Idec MA Inc.
发明人： LEE, Wen-Cherng , CARTER, Mary, Beth , CHUAQUI, Claudio , GUCKIAN, Kevin , LIN, Edward, Yin-shiang , CHOI, Michael, J. , DENG, Zhan , BORIACK-SJODIN, Paula, Ann , SUN, Lihong
IPC分类号： C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D419/14 , A61K31/4184 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14
摘要： The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.
摘要翻译： 本发明涉及作为TGFβ家族I型受体拮抗剂的式（I）化合物，Alk5和/或Alk4，组合物和使用方法。 式（I）化合物可以用于预防和/或治疗诸如纤维化（例如肾纤维化，肺纤维化和肝纤维化），进行性癌症或其他TGFβ家族信号活性降低的疾病 是可取的。
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公开(公告)号：EP0842196B1
公开(公告)日：2007-11-21
申请号：EP96924444.1
申请日：1996-07-11
申请人： Biogen Idec MA Inc.
发明人： LIN, Ko-Chung , ADAMS, Steven, P. , CASTRO, Alfredo, C. , ZIMMERMAN, Craig, N. , CUERVO, Julio, Hernan , LEE, Wen-Cherng , HAMMOND, Charles, E. , CARTER, Mary, Beth , ALMQUIST, Ronald, G. , ENSINGER, Carol, Lee
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical composition of this inveniton can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：EP1786803A1
公开(公告)日：2007-05-23
申请号：EP05789976.7
申请日：2005-08-24
申请人： Biogen Idec MA, Inc.
发明人： LEE, Wen-Cherng , SUN, Lihong , CHUAQUI, Claudio , CORNEBISE, Mark , SINGH, Juswinder , SHAN, Feng
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , C07D405/14 , C07D471/04 , C07D403/14
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14
摘要： The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention features a compound of formula (I) and uses thereof: formula (I).
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公开(公告)号：EP1778717A2
公开(公告)日：2007-05-02
申请号：EP05770730.9
申请日：2005-07-08
申请人： Biogen Idec MA, Inc.
IPC分类号： C07K5/06 , C07D403/02
CPC分类号： C07K5/06165
摘要： Cell adhesion inhibitors can interact with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. An inhibitor including a polyethylene glycol moiety can have advantageous pharmaceutical properties.
摘要翻译： 细胞粘附抑制剂可以与VLA-4分子相互作用并抑制VLA-4依赖性细胞粘附。 包含聚乙二醇部分的抑制剂可具有有利的药物性质。
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公开(公告)号：EP1265606B9
公开(公告)日：2007-02-28
申请号：EP00959232.0
申请日：2000-08-14
申请人： Biogen Idec MA Inc.
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/445 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D207/16 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07K5/02 , C07K5/06
CPC分类号： C07D401/06 , A61K38/00 , C07D205/04 , C07D207/16 , C07D207/48 , C07D209/42 , C07D211/32 , C07D265/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07K5/0215 , C07K5/06165 , C07K5/06191
摘要： A cell adhesion inhibitor of the general formula: R?3-L-L'-R1¿ is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.
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公开(公告)号：EP1973909A2
公开(公告)日：2008-10-01
申请号：EP06848155.5
申请日：2006-12-22
申请人： Biogen Idec MA Inc.
发明人： LEE, Wen-Cherng , CHUAQUI, Claudio , SUN, Lihong , HOEMANN, Michael , NIU, Deqiang , YAN, Dingxue , BONAFOUX, Dominique , CORNEBISE, Mark
IPC分类号： C07D471/04 , C07D487/04 , C07D491/20 , C07D519/00 , A61K31/437 , A61K31/55 , A61K31/4985 , A61P9/00 , A61P11/00 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to compounds of formula I that are modulators of Transforming Growth Factor β (TGF β) and are useful for treating TGF β related diseases. In Formula (I) one of Rl or R2 is heteroaryl and the other is aryl or heteroaryl, one of Xl or X2 is C and the other is N.
摘要翻译： 本发明涉及式I化合物，其是转化生长因子β（TGFβ）的调节剂并且可用于治疗TGFβ相关疾病。 在式（I）中，R1或R2之一是杂芳基，另一个是芳基或杂芳基，X1或X2之一是C，另一个是N.
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