公开(公告)号：EP2310403A2

公开(公告)日：2011-04-20

申请号：EP09772554.3

申请日：2009-07-03

申请人： Biomérieux S.A.

发明人： BIEBL, Manfred ,  GRASSL, Renate ,  WALTER, Monika ,  MILLER, Stefan

IPC分类号： C07K14/005 ,  C12N9/24 ,  G01N33/569

CPC分类号： C07K14/005 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C12N2700/00 ,  C12N2795/10322 ,  G01N33/56911 ,  G01N2333/005

摘要： The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.

摘要翻译： 本发明涉及与革兰氏阴性细菌的O-抗原结合的噬菌体粘附蛋白，缺乏与噬菌体结合的能力和水解脂多糖的能力。 本发明还涉及包含编码根据本发明的蛋白质的序列的核酸分子。 本发明还涉及所述蛋白质的使用以及细菌的检测，纯化和富集的方法。

公开(公告)号：EP3124492A1

公开(公告)日：2017-02-01

申请号：EP16188008.3

申请日：2009-07-03

申请人： bioMérieux S.A.

发明人： BIEBL, Manfred ,  GRASSL, Renate ,  WALTER, Monika ,  MILLER, Stefan

IPC分类号： C07K14/005 ,  G01N33/569

CPC分类号： C07K14/005 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C12N2700/00 ,  C12N2795/10322 ,  G01N33/56911 ,  G01N2333/005

摘要： The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysacchaiides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.

摘要翻译： 本发明涉及与革兰氏阴性菌的O-抗原结合的噬菌体粘附蛋白，其缺乏结合噬菌体和水解脂多糖的能力。 本发明进一步涉及包含编码根据本发明的蛋白质的序列的核酸分子。 此外，本发明涉及根据本发明的产生噬菌体粘附蛋白的方法。 本发明进一步涉及所述蛋白质的用途以及检测，纯化和富集细菌的方法。

公开(公告)号：EP2310403B1

公开(公告)日：2017-12-06

申请号：EP09772554.3

申请日：2009-07-03

申请人： Biomérieux S.A.

发明人： BIEBL, Manfred ,  GRASSL, Renate ,  WALTER, Monika ,  MILLER, Stefan

IPC分类号： C07K14/005 ,  C12N9/24 ,  G01N33/569

CPC分类号： C07K14/005 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C12N2700/00 ,  C12N2795/10322 ,  G01N33/56911 ,  G01N2333/005