公开(公告)号：EP1850854A1

公开(公告)日：2007-11-07

申请号：EP05724171.3

申请日：2005-02-25

申请人： Biomarin Pharmaceutical Inc.

发明人： MEDICIS PEDIATRICS, INC. ,  CLEMENTE, Emmett ,  PATEL, Bhiku ,  BHATIA, Kuljit ,  SORGI, Frank, L. ,  KAKKIS, Emil, D.

IPC分类号： A61K31/545

CPC分类号： A61K9/0095 ,  A61K47/26

摘要： A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a drug dissolved or dispersed in an aqueous medium. The aqueous medium consists essentially of water, about 3% to about 10% w/v polyvinylpyrrolidone, about 60% to about 75% w/v of C3-C6 polyol that includes more than 55% w/v of a non-reducing disaccharide, trisaccharide or tetrasaccharide such as sucrose, optionally about 0.0 1% to about 0.5% w/v of a glycyrrhetic acid, glycyrrhizinate derivative or salt thereof, and one or more flavorants, and preferably includes one or more preservatives. The liquid composition is room temperature stable, and may have a pleasant taste.