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公开(公告)号：EP3322715A1
公开(公告)日：2018-05-23
申请号：EP15739551.8
申请日：2015-07-14
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , JPT Peptide Technologies GmbH
发明人： SAHIN, Ugur , PLUM, Laura Maria , FIEDLER, Markus , DANESCHDAR, Matin , SCHMOLDT, Hans-Ulrich , REIMER, Ulf , SCHNATBAUM, Karsten
IPC分类号： C07K7/06 , A61K38/08 , C07K14/725
CPC分类号： C07K7/06 , A61K38/00 , C07K14/7051 , C07K2319/00 , G01N2333/7051
摘要： The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3ε). These molecules compete with CD3ε for binding to a CD3ε binding domain, e.g. a CD3ε binding domain of an antibody, and are capable of detecting antibodies against CD3ε. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3ε antibody purification and the detection of anti-CD3ε antibodies in biological samples.
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公开(公告)号：EP3099706A1
公开(公告)日：2016-12-07
申请号：EP14701918.6
申请日：2014-01-29
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , JPT Peptide Technologies GmbH
发明人： SAHIN, Ugur , DANESCHDAR, Matin , SCHMOLDT, Hans-Ulrich , PLUM, Laura-Marie , FIEDLER, Markus , REIMER, Ulf , SCHNATBAUM, Karsten
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K39/0005 , G01N33/5308 , G01N33/57492 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.
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公开(公告)号：EP3271385B1
公开(公告)日：2019-07-03
申请号：EP16712761.2
申请日：2016-03-15
申请人： Biontech AG
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公开(公告)号：EP3099706B1
公开(公告)日：2018-10-31
申请号：EP14701918.6
申请日：2014-01-29
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , JPT Peptide Technologies GmbH
发明人： SAHIN, Ugur , DANESCHDAR, Matin , SCHMOLDT, Hans-Ulrich , PLUM, Laura-Marie , FIEDLER, Markus , REIMER, Ulf , SCHNATBAUM, Karsten
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K39/0005 , G01N33/5308 , G01N33/57492 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.
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公开(公告)号：EP3271385A1
公开(公告)日：2018-01-24
申请号：EP16712761.2
申请日：2016-03-15
申请人： Biontech AG
发明人： SAHIN, Ugur , WÜSTEHUBE-LAUSCH, Joycelyn , FIEDLER, Markus , DANESCHDAR, Matin , SCHMOLDT, Hans-Ulrich
CPC分类号： C07K14/811 , C12Y304/21026
摘要： The present invention relates to the diagnosis and treatment of cancerous diseases, in particular cancerous diseases expressing Seprase (Fap-alpha; fibroblast activation protein alpha). More particularly, the invention concerns peptides targeting Seprase.
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