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    USE OF PEDF-DERIVED POLYPEPTIDES FOR TREATING ALOPECIA AND/OR HAIR DEPIGMENTATION
    1.
    发明授权
    USE OF PEDF-DERIVED POLYPEPTIDES FOR TREATING ALOPECIA AND/OR HAIR DEPIGMENTATION 有权

    公开(公告)号：EP2895502B1

    公开(公告)日：2018-09-05

    申请号：EP12884514.6

    申请日：2012-09-17

    Applicant: Mackay Memorial Hospital

    Inventor： TSAO, Yeou-Ping ,  HO, Tsung-Chuan

    IPC: C07K14/81 ,  A61K38/00

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/811

    Abstract: A method for treating alopecia and/or hair depigmentation includes administering to a subject in need of such treatments a synthetic peptide, which has an amino acid sequence that has 20-44 amino acid residues and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 16-35 of SEQ ID NO: 10. Also disclosed herein are pharmaceutical compositions containing the synthetic peptide; and uses thereof. According to various embodiments of the present disclosure, the synthetic peptide is useful in treating alopecia and/or hair depigmentation in a subject.

    ECOTIN VARIANTS
    2.
    发明公开
    ECOTIN VARIANTS 审中-公开

    公开(公告)号：EP3201214A4

    公开(公告)日：2018-04-04

    申请号：EP15847167

    申请日：2015-10-01

    Applicant: ANSUN BIOPHARMA INC

    Inventor： FANG FANG

    IPC: C07K14/81

    CPC classification number: C07K14/811 ,  A61K38/00 ,  C07K14/8107

    Abstract: Ecotin variants and their use in treating viral hemorrhagic fever are described. Described herein are methods for treating systemic inflammatory response syndrome or viral hemorrahagic fever by administering an ecotin polypeptide. Described herein is a polypeptide comprising the amino acid sequence of any of SEQ ID NOs: 2-9 and 11-18. Also described: is a polypeptide comprising the amino acid sequence of any of SEQ ID NO: 11-18 preceded by a methionine; a polypeptide comprising the amino acid sequence of any of SEQ ID NO: 11 -18 with up to 5 single amino acid changes or deletions provided that the polypeptide does not comprise the amino acid sequence of SEQ ID NO: 10.

    HIGH-SELECTIVITY CONTACT ACTIVATION INHIBITOR BASED ON INFESTIN-4
    6.
    发明公开
    HIGH-SELECTIVITY CONTACT ACTIVATION INHIBITOR BASED ON INFESTIN-4 审中-公开
    HOCHSELEKTIVER KONTAKTAKTIVIERUNGSINHIBITOR AUF DER BASIS VON INFESTIN-4

    公开(公告)号：EP3075742A4

    公开(公告)日：2017-04-26

    申请号：EP14865083

    申请日：2014-11-25

    Applicant: OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU «GEMATOLOGICHESKAYA KORPORATSIYA»

    Inventor： KOLYADKO VLADIMIR NIKOLAEVICH ,  ATAULLAKHANOV FAZOIL INOYATOVICH ,  PANTELEEV MIKHAIL ALEKSANDROVICH ,  VUYMO TATYANA ALEKSEEVNA ,  OVSEPYAN RUZANNA ARMENOVNA ,  SUROV STEPAN SERGEEVICH ,  KORNEEVA VERA ANATOLIEVNA

    IPC: C07K14/435 ,  C07K14/81 ,  C12Q1/56 ,  G01N33/86

    CPC classification number: C12Q1/56 ,  C07K14/435 ,  C07K14/81 ,  C07K14/811 ,  G01N33/86 ,  G01N2333/96458

    Abstract: The present invention relates to medicine, and specifically to hematology, and can be used in particular for diagnostic and research purposes when determining coagulation characteristics of blood and its components, and also in biotechnology and fundamental biological research. One of the aspects of the present invention is a polypeptide for inhibition of contact activation in a sample of blood or its product to be tested, which comprises the sequence of an infestin-4 mutant MutB (SEQ ID NO: 1) and which substantially corresponds thereto, where said sequence can have modifications outside the area of the inhibitory loop which significantly maintain the activity of the said polypeptide, which acts as a high-selectivity fXIIa inhibitor, the selectivity of which is higher than that of native infestin-4 and Mut15, or the activity of which is higher than that of native infestin-4 and Mut15. Another aspect of the invention is the use of the said polypeptide to study the coagulation in the test sample of blood or its product, including at least one of the following steps, and preferably all of the following steps: obtaining a sample, bringing it into contact with the said polypeptide, and incubating the resulting mixture, bringing a blood coagulation activator into contact with the sample containing the said polypeptide, and measuring the coagulation parameters of the sample. Yet another aspect of the invention is the use of a polypeptide comprising the sequence of an infestin-4 mutant MutB as an anticoagulant which blocks contact activation by means of bringing s sample into contact with the said polypeptide for collection purposes and in order to increase the storage time of the sample.

    Abstract translation: 本发明涉及医学，特别是血液学，并且在确定血液及其组分的凝固特性时，以及在生物技术和基础生物学研究中可以特别用于诊断和研究目的。 本发明的一个方面是用于抑制血液或其待测产物样品中接触活化的多肽，其包含稻疱菌素-4突变体MutB（SEQ ID NO：1）的序列并且其基本上对应于 其中所述序列可以在抑制环区域外具有修饰，其显着维持所述多肽的活性，所述多肽充当高选择性fXIIa抑制剂，其选择性高于天然infestin-4和Mut15的选择性 ，或其活性高于天然infestin-4和Mut15的活性。 本发明的另一方面是使用所述多肽来研究血液或其产物的测试样品中的凝血，包括至少一个以下步骤，并且优选所有以下步骤：获得样品，使其进入 与所述多肽接触，孵育所得混合物，使血液凝固活化剂与含有所述多肽的样品接触，并测量样品的凝固参数。 本发明的又一个方面是包含infestin-4突变体MutB序列的多肽作为抗凝血剂的用途，其通过使s样品与所述多肽接触用于收集目的而阻断接触激活，并且为了增加 样品的储存时间。

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