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公开(公告)号：EP2618835A1
公开(公告)日：2013-07-31
申请号：EP11761508.8
申请日：2011-09-19
申请人： Biontech AG , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及提供抗原特异性淋巴样细胞的有效方法。 这些淋巴样细胞可用于提供具有确定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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公开(公告)号：EP2714071A2
公开(公告)日：2014-04-09
申请号：EP12723117.3
申请日：2012-05-23
申请人： Biontech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , KREITER, Sebastian , DIKEN, Mustafa , DIEKMANN, Jan , KOSLOWSKI, Michael , BRITTEN, Cedrik , CASTLE, John , LÖWER, Martin , RENARD, Bernhard , OMOKOKO, Tana , DE GRAAF, Johannes Hendrikus
CPC分类号： A61K39/0011 , C12Q1/6886 , C12Q2600/156 , G16B20/00 , G16B40/00
摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
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公开(公告)号：EP3213765A2
公开(公告)日：2017-09-06
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
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公开(公告)号：EP3514172B1
公开(公告)日：2020-03-11
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
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公开(公告)号：EP3213765B1
公开(公告)日：2019-08-28
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
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公开(公告)号：EP3514172A1
公开(公告)日：2019-07-24
申请号：EP19151238.3
申请日：2015-03-30
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH , Ganymed Pharmaceuticals GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , HOFF, Holger , VOSS, Ralf-Holger , BREITKREUZ, Andrea , HOBOHM, Kathleen , MROZ, Karolina Anna
IPC分类号： C07K14/725 , C07K14/47 , A61P35/00 , A61K35/26
摘要： The present invention provides Claudin-6-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP2618835B1
公开(公告)日：2017-07-05
申请号：EP11761508.8
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
摘要翻译： 本发明涉及提供抗原特异性淋巴细胞的有效方法。 这些淋巴细胞可用于提供具有限定的MHC限制的抗原特异性T细胞受体并鉴定免疫学相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。
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8.发明公开
公开(公告)号：EP4082565A1
公开(公告)日：2022-11-02
申请号：EP22166898.1
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , BREITKREUZ, Andrea , MROZ, Karolina Anna , HEBICH, Lisa
IPC分类号： A61K39/00 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/725 , C07K16/28 , C07K14/705
摘要： The present invention provides Claudin-18.2-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP3590530A1
公开(公告)日：2020-01-08
申请号：EP19193391.0
申请日：2011-09-19
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
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公开(公告)号：EP2714071B1
公开(公告)日：2019-07-10
申请号：EP12723117.3
申请日：2012-05-23
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
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