公开(公告)号：EP1831225A2

公开(公告)日：2007-09-12

申请号：EP05857011.0

申请日：2005-11-21

申请人： The Regents of the University of California ,  Bioseek, Inc. ,  Shokat, Kevan M.

发明人： SEPETOV, Nikolai ,  ZHANG, Chao ,  GSCHWEND, Hienz ,  KUNKEL, Eric, J.

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.

公开(公告)号：EP2135078A1

公开(公告)日：2009-12-23

申请号：EP08742040.2

申请日：2008-03-10

申请人： Bioseek, Inc.

发明人： KUNKEL, Eric, J. ,  ROSLER, Elen, S. ,  PRIVAT, Sylvie ,  MELROSE, Jennifer, E.

IPC分类号： G01N33/50 ,  G06F19/00 ,  A61K31/00 ,  C12Q1/00

CPC分类号： G01N33/6893 ,  G01N33/5055 ,  G01N33/5064 ,  G01N33/5067 ,  G01N2800/085 ,  G01N2800/10 ,  G01N2800/382

摘要： Agents that stabilize and/or prevent fibrosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on matrix deposition and remodeling, epithelial health, and inflammation. Treatment for fibrosis is provided using compositions of the invention.

公开(公告)号：EP1668361A2

公开(公告)日：2006-06-14

申请号：EP04788596.7

申请日：2004-09-02

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  MELROSE, Jennifer ,  KUNKEL, Eric, J.

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/5041 ,  G01N33/5023 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

摘要： Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify patterns of expression of physiologically important cell surface and secreted molecules. Combinations of multiple cell types may be utilized. Systems encompassing multiple cell types not only respond to perturbations of each cell type's intracellular signaling networks, but also to inhibition of pathways of communication between cells. Readout information may be combined in multi-system analysis, where the profiles obtained from multiple systems are combined in order to provide enhanced resolution for agent classification.