公开(公告)号：EP1668361A2

公开(公告)日：2006-06-14

申请号：EP04788596.7

申请日：2004-09-02

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  MELROSE, Jennifer ,  KUNKEL, Eric, J.

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/5041 ,  G01N33/5023 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

摘要： Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify patterns of expression of physiologically important cell surface and secreted molecules. Combinations of multiple cell types may be utilized. Systems encompassing multiple cell types not only respond to perturbations of each cell type's intracellular signaling networks, but also to inhibition of pathways of communication between cells. Readout information may be combined in multi-system analysis, where the profiles obtained from multiple systems are combined in order to provide enhanced resolution for agent classification.

公开(公告)号：EP1436617B1

公开(公告)日：2010-10-27

申请号：EP02775804.4

申请日：2002-09-13

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  BUTCHER, Eugene, C. ,  MELROSE, Jennifer

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/50

CPC分类号： G01N33/5091 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N33/6872 ,  G06F19/12 ,  G06F19/24 ,  G06F19/26

摘要： Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.

公开(公告)号：EP1719051A1

公开(公告)日：2006-11-08

申请号：EP05723299.3

申请日：2005-02-17

申请人： Bioseek, Inc.

发明人： ROSLER, Elen ,  KUNKEL, Eric J. ,  PRIVAT, Sylvie ,  MELROSE, Jennifer ,  FISCHER, Melissa ,  BERG, Ellen L.

IPC分类号： G06F7/00 ,  G01N33/48 ,  G01N33/50 ,  G06G7/48

CPC分类号： G01N33/5008 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5061 ,  G01N2800/122 ,  G06F19/20 ,  G06F19/706

摘要： Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.

公开(公告)号：EP1436617A2

公开(公告)日：2004-07-14

申请号：EP02775804.4

申请日：2002-09-13

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  BUTCHER, Eugene, C. ,  MELROSE, Jennifer

IPC分类号： G01N33/53

CPC分类号： G01N33/5091 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N33/6872 ,  G06F19/12 ,  G06F19/24 ,  G06F19/26

摘要： Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.

公开(公告)号：EP1872293A2

公开(公告)日：2008-01-02

申请号：EP06739889.1

申请日：2006-03-28

申请人： Bioseek, Inc.

发明人： MELROSE, Jennifer ,  ROSLER, Elen ,  FISCHER, Melissa ,  PRIVAT, Sylvie ,  KUNKEL, Eric J. ,  BERG, Ellen

IPC分类号： G06F19/00

CPC分类号： G06F19/18 ,  G06F19/12 ,  G06F19/24 ,  G06F19/704

摘要： Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.

摘要翻译： 提供了用于评估生物数据集简档有关的炎性心血管疾病的方法和系统，其中包括用于多个蜂窝参数的信息的数据集进行比较，并鉴定，并在候选药物制剂的评价用于适合作为治疗剂。

公开(公告)号：EP1269187A1

公开(公告)日：2003-01-02

申请号：EP01914718.0

申请日：2001-03-06

申请人： Bioseek, Inc.

发明人： BERG, Ellen, L. ,  BUTCHER, Eugene, C. ,  MELROSE, Jennifer ,  PLAVEC, Ivan

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/505 ,  C12Q1/06 ,  G01N5/00 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5061 ,  G01N33/5064 ,  G01N33/5091 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N33/6872 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2500/10 ,  G01N2510/00

摘要： A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.