公开(公告)号：EP1971578A1

公开(公告)日：2008-09-24

申请号：EP06820701.8

申请日：2006-12-22

申请人： Biotica Technology Limited

发明人： MARTIN, Christine, Janet ,  WILKINSON, Barrie ,  GAISSER, Sabine ,  ZHANG, Ming-Qiang ,  SHERIDAN, Rose, Mary ,  SHEEHAN, Lesley Sarah ,  LILL, Rachel, Edith ,  NUR-E-ALAM, Mohammed ,  VOUSDEN, William, Alexander

IPC分类号： C07D225/06 ,  A61K31/395 ,  A61P35/00

CPC分类号： C07D225/06

摘要： The present invention relates to 21-deoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.