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公开(公告)号：EP2683711B8
公开(公告)日：2017-08-23
申请号：EP12754287.6
申请日：2012-03-06
发明人： PIHLAVISTO, Marjo , SMITH, David , JUHAKOSKI, Auni , FULOP, Ferenc , LAZAR, Laszlo , SZATMARI, Istvan , MIKLOS, Ferenc , SZAKONYI, Zsolt , KISS, Lorand , PALKO, Marta
IPC分类号： C07D237/16 , C07D237/24 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , A61K31/50 , A61P29/00
CPC分类号： C07D237/24 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/5377 , A61K45/06 , C07C57/15 , C07D237/16 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , G01N33/502
摘要： The invention relates to pyridazinone and pyridone compounds having formula (I) or (I′), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R1/R4 and X and X3 are as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译： 本发明涉及具有式（I）或（I'）的哒嗪酮和吡啶酮化合物及其药学上可接受的盐，水合物和溶剂合物（I），其中R 1 / R 4以及X和X 3如权利要求中所定义。 本发明进一步涉及它们作为含铜胺氧化酶抑制剂的用途。 本发明还涉及上述化合物的制备以及包含一种或多种上述化合物，其药学上可接受的盐，水合物或溶剂合物作为活性成分的药物组合物。
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公开(公告)号：EP2683711B1
公开(公告)日：2017-02-01
申请号：EP12754287.6
申请日：2012-03-06
发明人： PIHLAVISTO, Marjo , SMITH, David , JUHAKOSKI, Auni , FULOP, Ferenc , LAZAR, Laszlo , SZATMARI, Istvan , MIKLOS, Ferenc , SZAKONYI, Zsolt , KISS, Lorand , PALKO, Marta
IPC分类号： C07D237/16 , C07D237/24 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , A61K31/50 , A61P29/00
CPC分类号： C07D237/24 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/5377 , A61K45/06 , C07C57/15 , C07D237/16 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , G01N33/502
摘要： The invention relates to pyridazinone and pyridone compounds having formula (I) or (I′), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R1/R4 and X and X3 are as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译： 本发明涉及具有式（I）或（I'）的哒嗪酮和吡啶酮化合物及其药学上可接受的盐，水合物和溶剂化物（Ⅰ），其中R1 / R4和X和X3如权利要求中所定义。 本发明还涉及它们作为含铜胺氧化酶抑制剂的用途。 本发明还涉及上述化合物的制备以及包含一种或多种上述化合物，其药学上可接受的盐，水合物或溶剂合物作为活性成分的药物组合物。
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公开(公告)号：EP2683711A1
公开(公告)日：2014-01-15
申请号：EP12754287.6
申请日：2012-03-06
发明人： PIHLAVISTO, Marjo , SMITH, David , JUHAKOSKI, Auni , FULOP, Ferenc , LAZAR, Laszlo , SZATMARI, Istvan , MIKLOS, Ferenc , SZAKONYI, Zsolt , KISS, Lorand , PALKO, Marta
IPC分类号： C07D403/04 , C07D237/16 , C07D237/18 , C07D403/12 , C07D401/04 , C07D413/04 , C07D409/04 , C07D403/14 , C07D237/22 , C07D493/00 , C07D401/14 , C07D413/14 , A61K31/50 , A61K31/4412 , A61P29/00
CPC分类号： C07D237/24 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/5377 , A61K45/06 , C07C57/15 , C07D237/16 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , G01N33/502
摘要： The invention relates to pyridazinone and pyridone compounds having formula (I) or (I′), and pharmaceutically acceptable salts, hydrates, and solvates thereof (I) wherein R1/R4 and X and X3 are as defined in the claims. The invention further relates to their use as inhibitors of copper-containing amine oxidases. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds, pharmaceutically acceptable salts, hydrates, or solvates thereof.
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