专利检索 ap:("Biovec LLC") AND inv:"SEHGALL, Lakshman, R." 第 1 页

1.

发明公开
EX VIVO AND IN VIVO EXPRESSION OF THE THROMBOMODULIN GENE FOR THE TREATMENT OF CARDIOVASCULAR AND PERIPHERAL VASCULAR DISEASES 审中-公开
标题翻译：离体和体内表达DESTHROMBOMODULIN基因心血管疾病和血管疾病的外围设备的处理

公开(公告)号：EP1573005A2

公开(公告)日：2005-09-14

申请号：EP03796526.6

申请日：2003-12-02

申请人： Biovec LLC

发明人： SEHGALL, Lakshman, R. , WONG, Jonathan

IPC分类号： C12N15/00 , A61K31/70

CPC分类号： A61K48/0058 , A61K38/366 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2800/30 , C12N2830/008 , C12N2830/42

摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.