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1.发明公开EX VIVO AND IN VIVO EXPRESSION OF THE THROMBOMODULIN GENE FOR THE TREATMENT OF CARDIOVASCULAR AND PERIPHERAL VASCULAR DISEASES 审中-公开离体和血栓调节蛋白基因的心血管病和血管疾病外设的治疗体内表达
公开(公告)号：EP2099438A2
公开(公告)日：2009-09-16
申请号：EP07772782.4
申请日：2007-03-14
申请人： Biovec LLC
IPC分类号： A61K31/00 , A61K31/713 , C07H21/00
CPC分类号： C12N15/86 , A61K31/198 , A61K38/366 , A61K38/42 , A61K45/06 , A61K48/005 , A61K48/0058 , C12N2710/10343 , A61K2300/00
摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel in vivo using a gutless adenovirus vector. Another. aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM.protein or its variant using a stent.
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2.发明公开IN VIVO AND EX VIVO GENE TRANSFER INTO RENAL TISSUE USING GUTLESS ADENOVIRUS VECTORS 有权甲无肠腺病毒载体的吲哚胺2,3-加氧酶及其USE IN肾脏疾病的治疗
公开(公告)号：EP2393497A1
公开(公告)日：2011-12-14
申请号：EP09839006.5
申请日：2009-02-17
申请人： Biovec LLC
IPC分类号： A61K31/7088 , A61P13/12 , A61K39/235 , A61K31/7105 , A61K38/36
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
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3.发明授权A GUTLESS ADENOVIRUS VECTOR COMPRISING INDOLEAMINE 2,3-DIOXYGENASE AND ITS USE IN THE TREATMENT OF RENAL DISEASE 有权甲无肠腺病毒载体的吲哚胺2,3-加氧酶及其USE IN肾脏疾病的治疗
公开(公告)号：EP2393497B1
公开(公告)日：2014-04-02
申请号：EP09839006.5
申请日：2009-02-17
申请人： Biovec LLC
IPC分类号： A61K39/235 , A61K38/36 , A61K38/44 , A61P13/12 , A61K39/00 , A61K48/00 , C07K14/745 , C12N7/00 , C12N15/86
CPC分类号： C12N15/86 , A61K38/00 , A61K38/44 , A61K39/001 , A61K48/00 , A61K48/005 , A61K48/0058 , A61K48/0075 , C07K14/7455 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12Y113/11052
摘要： A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
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4.发明公开EX VIVO AND IN VIVO EXPRESSION OF THE THROMBOMODULIN GENE FOR THE TREATMENT OF CARDIOVASCULAR AND PERIPHERAL VASCULAR DISEASES 审中-公开离体和体内表达DESTHROMBOMODULIN基因心血管疾病和血管疾病的外围设备的处理
公开(公告)号：EP1573005A2
公开(公告)日：2005-09-14
申请号：EP03796526.6
申请日：2003-12-02
申请人： Biovec LLC
CPC分类号： A61K48/0058 , A61K38/366 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2800/30 , C12N2830/008 , C12N2830/42
摘要： The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the present invention relates to a method for treating a vascular disease by introducing a DNA sequence encoding a TM protein or its variant into a segment of a blood vessel ex vitro using a gutless adenovirus vector. Another aspect of the present invention is to provide a method to deliver a gutless adenovirus vector carrying a DNA sequence encoding a TM protein or its variant using a stent.
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