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公开(公告)号：EP3326643A1
公开(公告)日：2018-05-30
申请号：EP17194648.6
申请日：2010-12-06
发明人： DUMONT, Jennifer, A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg M. , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61K38/37 , A61K47/68 , A61K47/64 , C07K14/755 , A61P7/04
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30 , Y02A90/26
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP3513804A1
公开(公告)日：2019-07-24
申请号：EP18211156.7
申请日：2012-07-06
发明人： DUMONT, Jennifer A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg , NUGENT, Karen , LI, Lian , PETERS, Robert
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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3.发明授权FACTOR VIII-FC CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF 有权因子VIII-FC嵌合和杂合多肽及其使用方法
公开(公告)号：EP2506868B1
公开(公告)日：2017-11-15
申请号：EP10835255.0
申请日：2010-12-06
发明人： DUMONT, Jennifer, A. , LOW, Susan , BITONTI, Alan, J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61K38/37 , C07K14/755 , C07K16/46 , A61P7/04
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
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4.发明授权
公开(公告)号：EP2870250B1
公开(公告)日：2018-04-18
申请号：EP13813225.3
申请日：2013-07-05
IPC分类号： C12N15/85
CPC分类号： C07K14/755 , A61K35/00 , A61K38/00 , C07K2319/30 , C07K2319/31
摘要： The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing single chain FVIII polypeptides, single chain FVIII polypeptides, and methods of treating Hemophilia A with a single chain Factor VIII polypeptide.
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公开(公告)号：EP4169525A1
公开(公告)日：2023-04-26
申请号：EP22163636.8
申请日：2012-07-06
发明人： DUMONT, Jennifer , LOW, Susan , BITONTI, Alan J. , GLENN, Pierce , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61K38/37 , A61K47/60 , A61K47/68 , A61P7/04 , C07K14/755
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP4382170A3
公开(公告)日：2024-09-04
申请号：EP24152910.6
申请日：2010-12-06
发明人： DUMONT, Jennifer , LOW, Susan , BITONTI, Alan J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg M. , NUGENT, Karen , LI, Lian , PETERS, Robert
CPC分类号： C07K2319/3020130101 , A61K47/643 , A61K47/6811 , A61K38/37 , C07K14/755 , A61P41/00 , A61P7/00 , A61P7/02 , A61P7/04 , Y02A90/10
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP4382170A2
公开(公告)日：2024-06-12
申请号：EP24152910.6
申请日：2010-12-06
发明人： DUMONT, Jennifer , LOW, Susan , BITONTI, Alan J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg M. , NUGENT, Karen , LI, Lian , PETERS, Robert
IPC分类号： A61P41/00
CPC分类号： C07K2319/3020130101 , A61K47/643 , A61K47/6811 , A61K38/37 , C07K14/755 , A61P41/00 , A61P7/00 , A61P7/02 , A61P7/04 , Y02A90/10
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP3906937A1
公开(公告)日：2021-11-10
申请号：EP21161784.0
申请日：2010-12-06
发明人： DUMONT, Jennifer A. , LOW, Susan , BITONTI, Alan J. , PIERCE, Glenn , LUK, Alvin , JIANG, Haiyan , MCKINNEY, Byron , OTTMER, Matt , SOMMER, Jurg M. , NUGENT, Karen , LI, Lian , PETERS, Robert
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：EP3404105A1
公开(公告)日：2018-11-21
申请号：EP18167850.9
申请日：2013-07-05
IPC分类号： C12N15/85
CPC分类号： C07K14/755 , A61K35/00 , A61K38/00 , C07K2319/30 , C07K2319/31
摘要： The present invention provides cell lines for producing single chain FVIII polypeptides, e.g., chimeric single chain FVIII polypeptides, methods of producing single chain FVIII polypeptides, single chain FVIII polypeptides, and methods of treating Hemophilia A with a single chain Factor VIII polypeptide.
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