公开(公告)号：EP3268376A1

公开(公告)日：2018-01-17

申请号：EP16712592.1

申请日：2016-03-09

申请人： Board of Regents, The University of Texas System

发明人： MULLER, Florian ,  MAXWELL, David, S. ,  BORNMANN, William, G. ,  LIN, Yu-Hsi ,  PRASAD, Basvoju, A Bhanu ,  PENG, Zhenghong ,  SUN, Duoli ,  SATANI, Nikuni ,  DIFRANSESCO, M., Emilia ,  DEPINHO, Ronald, A. ,  CZAKO, Barbara ,  PISANESCHI, Federica

IPC分类号： C07F9/553 ,  A61K31/662 ,  C07F9/572 ,  C07F9/59 ,  A61P35/00 ,  A61P31/00

CPC分类号： A61K31/675 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00 ,  C07F9/5532 ,  C07F9/572 ,  C07F9/59 ,  Y02A50/414 ,  Y02A50/415

摘要： Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.