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公开(公告)号：EP2888255B1
公开(公告)日：2018-07-18
申请号：EP13830374.8
申请日：2013-08-23
发明人： JONES, Philip , DIFRANCESCO, Maria, Emilia , PETROCCHI, Alessia , CARROLL, Christopher, L. , MARSZALEK, Joe , CZAKO, Barbara , JOHNSON, Ryan , THEROFF, Jay
IPC分类号： C07D413/14 , A61K31/497 , A61P35/00 , A61K31/506
CPC分类号： C07D495/04 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
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公开(公告)号：EP3164394A2
公开(公告)日：2017-05-10
申请号：EP15814723.1
申请日：2015-07-02
发明人： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC分类号： C07D401/06
摘要： Methods of inhibition GLS1 activity in a human or animal subject are also provided.
摘要翻译： 本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。
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公开(公告)号：EP2888256A2
公开(公告)日：2015-07-01
申请号：EP13831105.5
申请日：2013-08-23
发明人： JONES, Philip , DIFRANCESCO, Maria, Emilia , PETROCCHI, Alessia , MARSZALEK, Joe , LIU, Gang , KANG, Zhijun , CARROLL, Christopher, L. , MCAFOOS, Timothy , CZAKO, Barbara
IPC分类号： C07D413/14 , A61K31/496 , A61P35/00
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/82 , C07D237/24 , C07D401/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
摘要翻译： 本发明涉及可用作HIF途径活性抑制剂的化合物和方法，用于治疗或预防癌症和其他缺氧介导的疾病。
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公开(公告)号：EP3164394B1
公开(公告)日：2020-04-01
申请号：EP15814723.1
申请日：2015-07-02
发明人： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC分类号： C07D401/14 , C07D405/14 , A61K45/06 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , C07D403/14 , C07D417/06 , C07D417/14 , C07D493/08 , C07D403/06
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公开(公告)号：EP2888255A2
公开(公告)日：2015-07-01
申请号：EP13830374.8
申请日：2013-08-23
发明人： JONES, Philip , DIFRANCESCO, Emilia , PETROCCHI, Alessia , CARROLL, Christopher L. , MARSZALEK, Joe , CZAKO, Barbara , JOHNSON, Ryan , THEROFF, Jay
IPC分类号： C07D413/14 , A61K31/497 , A61P35/00
CPC分类号： C07D495/04 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
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公开(公告)号：EP3268376A1
公开(公告)日：2018-01-17
申请号：EP16712592.1
申请日：2016-03-09
发明人： MULLER, Florian , MAXWELL, David, S. , BORNMANN, William, G. , LIN, Yu-Hsi , PRASAD, Basvoju, A Bhanu , PENG, Zhenghong , SUN, Duoli , SATANI, Nikuni , DIFRANSESCO, M., Emilia , DEPINHO, Ronald, A. , CZAKO, Barbara , PISANESCHI, Federica
CPC分类号： A61K31/675 , A61K45/06 , A61K2300/00 , A61P35/00 , C07F9/5532 , C07F9/572 , C07F9/59 , Y02A50/414 , Y02A50/415
摘要： Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.
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