公开(公告)号：EP2694116A2

公开(公告)日：2014-02-12

申请号：EP12767275.6

申请日：2012-04-06

申请人： Board of Regents of the University of Texas System ,  Alzeca Biosciences, Llc ,  Board of Regents of the University of Houston System ,  Texas Children's Hospital

发明人： ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/18

CPC分类号： A61K49/1812 ,  A61K47/6911 ,  A61K49/0466

摘要： Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer- amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer' s Disease.

摘要翻译： 提供了基于脂质的纳米颗粒组合物。 组合物通常包含脂质亲水性聚合物 - 淀粉样蛋白结合配体缀合物，并且可以是脂质体组合物。 组合物，包括脂质体组合物，可用于淀粉样蛋白的成像和/或治疗。 阿尔茨海默病特征斑块沉积。

公开(公告)号：EP2694116B1

公开(公告)日：2018-06-13

申请号：EP12767275.6

申请日：2012-04-06

申请人： Board of Regents of the University of Texas System ,  Alzeca Biosciences, Llc ,  Board of Regents of the University of Houston System ,  Texas Children's Hospital

发明人： ANNAPRAGADA, Ananth ,  ERIKSEN, Jason, L. ,  TANIFUM, Eric, A. ,  DASGUPTA, Indrani ,  COOK, Stephen, C.

IPC分类号： A61K49/18 ,  A61K49/04 ,  A61K47/69

CPC分类号： A61K49/1812 ,  A61K47/6911 ,  A61K49/0466

摘要： Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.