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1.发明公开(1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES 有权（1,2,4-）三唑并[4,3-A-]中草酸衍生物磷酸二酯酶
公开(公告)号：EP2670754A1
公开(公告)日：2013-12-11
申请号：EP12708774.0
申请日：2012-01-31
发明人： LANKAU, Hans-Joachim , LANGEN, Barbara , GRUNWALD, Christian , HÖFGEN, Norbert , STANGE, Hans , DOST, Rita , EGERLAND, Ute
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The invention relates to (1,2,4)triazolo[4,3-a]quinoxaline derivatives which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases.
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公开(公告)号：EP2882749B1
公开(公告)日：2018-04-04
申请号：EP13742632.6
申请日：2013-07-29
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FRATTINI, Sara , DI ANTONIO, Giustino , LANKAU, Hans-Joachim , STANGE, Hans , GRUNWALD, Christian , LANGEN, Barbara , EGERLAND, Ute , HÖFGEN, Norbert
IPC分类号： C07D471/14 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/14 , C07D471/14
摘要： The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
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3.发明授权(1,2,4)TRIAZOLO[4,3-A]QUINOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES 有权（1,2,4-）三唑并[4,3-A-]中草酸衍生物磷酸二酯酶
公开(公告)号：EP2670754B1
公开(公告)日：2017-05-24
申请号：EP12708774.0
申请日：2012-01-31
发明人： LANKAU, Hans-Joachim , LANGEN, Barbara , GRUNWALD, Christian , HÖFGEN, Norbert , STANGE, Hans , DOST, Rita , EGERLAND, Ute
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2882749A1
公开(公告)日：2015-06-17
申请号：EP13742632.6
申请日：2013-07-29
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FRATTINI, Sara , DI ANTONIO, Giustino , LANKAU, Hans-Joachim , STANGE, Hans , GRUNWALD, Christian , LANGEN, Barbara , EGERLAND, Ute , HÖFGEN, Norbert
IPC分类号： C07D471/14 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/14 , C07D471/14
摘要： The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
摘要翻译： 本发明涉及作为磷酸二酯酶2和/或10的抑制剂的通式（I）的4-甲基-2,3,5,9,9-五氮杂 - 环戊二烯并[a]萘衍生物，其可用于治疗中枢神经系统疾病 和其他疾病。 此外，本发明涉及制备药物组合物的方法以及制备本发明化合物的方法。
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