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1.发明公开PHENYL-3-AZA-BICYCLO[3.1.0]HEX-3-YL-METHANONES AND THE USE THEREOF AS MEDICAMENT 有权苯甲酰基-3-AZA-BICYCLO [3.1.0] HEX-3-YL-METHANONE UND DEREN VERWENDUNG ALS MEDIKAMENT
公开(公告)号：EP2739615A1
公开(公告)日：2014-06-11
申请号：EP12741022.3
申请日：2012-08-02
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FERRARA, Marco , LINGARD, Iain , MAZZAFERRO, Rocco , ROSENBROCK, Holger
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K31/421 , A61K31/427 , A61K31/437 , A61K31/4439 , A61P25/18 , A61P25/28
CPC分类号： C07D413/04 , C07D209/52 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： The present inventions relates to substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl- methanones of general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 and R
6 are as herein described or salts thereof, preferably pharmaceutically acceptable salts thereof. The invention further relates to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various conditions such as conditions concerning positive and negative symptoms of schizophrenia as well as cognitive impairments associated with schizophrenia, Alzheimers Disease and other neurological and psychiatric disorders. The compounds of the invention show glycine transporter-1 (GlyT1) inhibiting properties.摘要翻译： 甘氨酸转运体-1（GlyT1）抑制剂的取代苯基-3-氮杂 - 双环[3.1.0]己-3-基 - 甲酮。 这些可用于治疗精神分裂症，阿尔茨海默病和其他神经和精神疾病。
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公开(公告)号：EP3362453A1
公开(公告)日：2018-08-22
申请号：EP16788047.5
申请日：2016-10-12
发明人： HOENKE, Christoph , BERTANI, Barbara , FERRARA, Marco , FOSSATI, Giacomo , FRATTINI, Sara , GIOVANNINI, Riccardo , HOBSON, Scott
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of phosphodiesterase 2, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
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公开(公告)号：EP4126850A1
公开(公告)日：2023-02-08
申请号：EP21716133.0
申请日：2021-03-29
发明人： GERLACH, Kai , BERTANI, Barbara , FERRARA, Marco , FOSSATI, Giacomo , HOBSON, Scott , LESSEL, Uta Friederike , RUNGE, Frank , SEMPLE, Graeme , MUELLER-VIEIRA, Ursula , WIPPICH, Julian , XIONG, Yifeng
IPC分类号： C07D403/14 , A61P25/00 , A61K31/501 , A61K31/506
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4.发明授权PHENYL-3-AZA-BICYCLO[3.1.0]HEX-3-YL-METHANONES AND THE USE THEREOF AS MEDICAMENT 有权苯基-3-氮杂双环[3.1.0]己-3-基 - 甲酮及其作为药物
公开(公告)号：EP2739615B1
公开(公告)日：2017-03-15
申请号：EP12741022.3
申请日：2012-08-02
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FERRARA, Marco , LINGARD, Iain , MAZZAFERRO, Rocco , ROSENBROCK, Holger
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K31/421 , A61K31/427 , A61K31/437 , A61K31/4439 , A61P25/18 , A61P25/28
CPC分类号： C07D413/04 , C07D209/52 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D471/04
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公开(公告)号：EP2882749A1
公开(公告)日：2015-06-17
申请号：EP13742632.6
申请日：2013-07-29
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FRATTINI, Sara , DI ANTONIO, Giustino , LANKAU, Hans-Joachim , STANGE, Hans , GRUNWALD, Christian , LANGEN, Barbara , EGERLAND, Ute , HÖFGEN, Norbert
IPC分类号： C07D471/14 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/14 , C07D471/14
摘要： The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
摘要翻译： 本发明涉及作为磷酸二酯酶2和/或10的抑制剂的通式（I）的4-甲基-2,3,5,9,9-五氮杂 - 环戊二烯并[a]萘衍生物，其可用于治疗中枢神经系统疾病 和其他疾病。 此外，本发明涉及制备药物组合物的方法以及制备本发明化合物的方法。
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公开(公告)号：EP2882749B1
公开(公告)日：2018-04-04
申请号：EP13742632.6
申请日：2013-07-29
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FRATTINI, Sara , DI ANTONIO, Giustino , LANKAU, Hans-Joachim , STANGE, Hans , GRUNWALD, Christian , LANGEN, Barbara , EGERLAND, Ute , HÖFGEN, Norbert
IPC分类号： C07D471/14 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/14 , C07D471/14
摘要： The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
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