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1.发明公开PROCESS FOR MANUFACTURING DIHYDROPTERIDINONES AND INTERMEDIATES THEREOF 有权生产工艺DIHYDROPTERIDINONEN及其中间体
公开(公告)号：EP2627656A1
公开(公告)日：2013-08-21
申请号：EP11767449.9
申请日：2011-10-11
发明人： SCHNAUBELT, Juergen , HERTER, Rolf
IPC分类号： C07D475/00 , A61K31/525
CPC分类号： C07D475/00
摘要： The present invention relates to an improved process for manufacturing dihydropteridinones of general formula (12) as well as intermediates thereof, wherein the groups R
1 , R
2 , R
3 , R
4 , and R
5 have the meanings given in the claims and specification.-
2.发明公开HYDRATE UND POLYMORPHE DES 4-[[(7R)-8-CYCLOPENTYL-7-ETHYL-5,6,7,8-TETRAHYDRO-5-METHYL-4-6-OXO-2-PIPERIDINYL|]AMINO]-3-METHOXY-N-(1-METHYL-4-PIPERIDINYL)-BENZAMID, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开水合物和4的多晶型物 - [[（7R）-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基4-6-氧代-2-哌啶基]氨基] -3-甲氧基 -N-（1-甲基-4-哌啶基） - 苯甲酰胺，其制备方法及其作为药物的用途
公开(公告)号：EP1778691A1
公开(公告)日：2007-05-02
申请号：EP05772062.5
申请日：2005-08-11
发明人： LINZ, Guenter , SIEGER, Peter , KRAEMER, Gerd, F. , RALL, Werner , HERTER, Rolf , HOFFMANN, Matthias , SCHMID, Rolf
IPC分类号： C07D475/00 , C07D211/58 , A61P35/00 , A61K31/519
CPC分类号： C07D211/58 , C07D475/00
摘要： The invention relates to novel hydrates and novel polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl) benzamide, methods for the production thereof, and the use thereof as medicaments.
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公开(公告)号：EP2152703A2
公开(公告)日：2010-02-17
申请号：EP08759488.3
申请日：2008-05-09
IPC分类号： C07D451/10
CPC分类号： C07D451/10
摘要： The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X -, R, R1 , R2 , R3, R4, R3',R4', R6 and R6' can have the meanings indicated in the claims and in the description.
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4.发明授权PROCESS FOR MANUFACTURING DIHYDROPTERIDINONES AND INTERMEDIATES THEREOF 有权生产工艺DIHYDROPTERIDINONEN及其中间体
公开(公告)号：EP2627656B1
公开(公告)日：2014-08-20
申请号：EP11767449.9
申请日：2011-10-11
发明人： SCHNAUBELT, Juergen , HERTER, Rolf
IPC分类号： C07D475/00 , A61K31/525
CPC分类号： C07D475/00
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