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1.发明公开SÄUREADDITIONSSALZE DES 2-[2-[[(4-METHOXY-2,6-DIMETHYLPHENYL)SULFONYL]-(METHYL)AMINO]ETHOXY]-N-METHYL-N-[3-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]ACETAMIDS UND IHRE VERWENDUNG ALS BRADYKININ-B1 REZEPTOR ANTAGONISTEN 审中-公开作者2-酸加成盐[ - [[（4-甲氧基-2,6-二甲基苯基）磺酰基] - 2-（甲基）氨基]乙氧基] -N-甲基-N- [3-（4-甲基哌嗪-1-基）环己基 ]乙酰胺和它们作为缓激肽B1受体拮抗剂的用途
公开(公告)号：EP2601181A1
公开(公告)日：2013-06-12
申请号：EP11741454.0
申请日：2011-08-04
发明人： PACHUR, Thorsten , PFRENGLE, Waldemar , BIRK, Manfred , SCHNAUBELT, Juergen , WERTHMANN, Ulrike
IPC分类号： C07D295/135 , A61K31/495 , A61P29/00
CPC分类号： C07D295/155 , C07D295/135
摘要： The invention relates to the novel acid addition salts AB of the following free base of formula (A) or the enantiomer thereof with a physiologically acceptable acid B selected from the group consisting of hydrochloric acid, fumaric acid, and tartaric acid and to the polymorphs, hydrates, and solvates thereof.
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公开(公告)号：EP1917253A1
公开(公告)日：2008-05-07
申请号：EP06778214.4
申请日：2006-08-10
发明人： KRUEGER, Thomas , RIES, Uwe , SCHNAUBELT, Juergen , RALL, Werner , LEUTER, Zeno A. , DURAN, Adil , SOYKA, Rainer
IPC分类号： C07D265/36 , C07C205/45 , C07C211/45 , C07C233/18 , C07C233/13
CPC分类号： C07D265/36 , C07C45/71 , C07C49/84 , C07C201/08 , C07C221/00 , C07C233/13 , C07C233/18 , Y02P20/55 , C07C205/45 , C07C225/22
摘要： The invention relates to a method for producing betamimetics of formula (I), in which n represents 1 or 2; R1 represents hydrogen, halogen, C1-4 alkyl or O-C1-4 alkyl; R2 represents hydrogen, halogen, C1-4 alkyl or O-C1-4 alkyl, and; R3 represents hydrogen, C1-4 alkyl, OH, halogen, O-C1-4 alkyl, O-C1-4 alkylene-COOH, O-C1-4 alkylene-COO-C1-4-alkyl.
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3.发明授权PROCESS AND INTERMEDIATES FOR PREPARING INDANYLOXYDIHYDROBENZOFURANYL ACETIC ACID DERIVATIVES AS GPR40 AGONISTS 有权制备作为GPR40激动剂的茚氧基二氢苯并呋喃乙酸衍生物的方法和中间体
公开(公告)号：EP3049396B1
公开(公告)日：2017-11-15
申请号：EP14771872.0
申请日：2014-09-22
发明人： DAHMANN, Georg , WAGNER, Holger , ECKHARDT, Matthias , FRANK, Markus , SANTAGOSTINO, Marco , SCHNAUBELT, Juergen , STERTZ, Uwe , PACHUR, Thorsten
IPC分类号： C07D307/80
CPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D513/04
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4.发明授权REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES 有权REGIO选择性制备2-氨基-5- TRIFLUOROMETHYLPYRIMIDIN-衍生物
公开(公告)号：EP2464634B1
公开(公告)日：2016-11-30
申请号：EP10744917.5
申请日：2010-08-13
IPC分类号： C07D239/34 , C07D239/47 , C07D401/12
CPC分类号： C07D239/47 , C07D239/34 , C07D401/12
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公开(公告)号：EP2396308A1
公开(公告)日：2011-12-21
申请号：EP10703274.0
申请日：2010-02-11
IPC分类号： C07D295/135 , C07C311/29
CPC分类号： C07D295/135 , C07C311/29
摘要： The present invention relates to a method for producing compounds of general formula (I), in which m, n, R
1 , and R
2 are defined as described below, to enantiomers thereof, to diastereomers thereof, to mixtures thereof, and to salts thereof, in particular physiologically acceptable salts thereof having organic or inorganic acids or bases.-
6.发明公开PROCESS FOR MANUFACTURING DIHYDROPTERIDINONES AND INTERMEDIATES THEREOF 有权生产工艺DIHYDROPTERIDINONEN及其中间体
公开(公告)号：EP2627656A1
公开(公告)日：2013-08-21
申请号：EP11767449.9
申请日：2011-10-11
发明人： SCHNAUBELT, Juergen , HERTER, Rolf
IPC分类号： C07D475/00 , A61K31/525
CPC分类号： C07D475/00
摘要： The present invention relates to an improved process for manufacturing dihydropteridinones of general formula (12) as well as intermediates thereof, wherein the groups R
1 , R
2 , R
3 , R
4 , and R
5 have the meanings given in the claims and specification.-
7.发明授权3-(4-PIPERIDINYL)-2,3,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-2(1H)-ON 有权3-（4-哌啶基）-2,3,4,5-四氢-1,3-苯并二氮杂-2（1H） - 酮
公开(公告)号：EP1968952B1
公开(公告)日：2011-08-10
申请号：EP06847036.8
申请日：2006-12-21
IPC分类号： C07D243/04
CPC分类号： C07D401/04
摘要： The invention relates to a method for producing the compound 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepine-2(1H)-one of formula (I), which can be found as a structural element in CGRP antagonists that are suited especially for the oral treatment of migraine.
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8.发明公开3-(4-PIPERIDINYL)-2,3,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-2(1H)-ON 有权3-（4-哌啶基）-2,3,4,5-四氢-1,3-苯并二氮杂-2（1H） - 酮
公开(公告)号：EP1968952A2
公开(公告)日：2008-09-17
申请号：EP06847036.8
申请日：2006-12-21
IPC分类号： C07D243/04
CPC分类号： C07D401/04
摘要： The invention relates to a method for producing the compound 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepine-2(1H)-one of formula (I), which can be found as a structural element in CGRP antagonists that are suited especially for the oral treatment of migraine.
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公开(公告)号：EP1615947A2
公开(公告)日：2006-01-18
申请号：EP04759130.0
申请日：2004-04-06
发明人： DONSBACH, Kai , ECKER, Dieter , FRUTOS, Rogelio., Boehringer Ingelheim PharmaInc. , GALLOU, Fabrice, Boehringer Ingelheim Pharma. Inc. , GUTHEIL, Dieter , HADDAD, Nizar, Boehringer Ingelheim Pharma. Inc. , HAGENKOETTER, Robert , KEMMER, Dirk , KROEBER, Jutta , NICOLA, Thomas , SCHNAUBELT, Juergen , SCHUL, Michael , SIMPSON, Robert, Donald , WEI, Xudong, Boehringer Ingelheim Pharma. Inc. , WINTER, Eric , XU, Yibo, Boehringer Ingelheim Pharmaceuticals Inc , YEE, Nathan, K., Boehringer Ingelheim Pharma. Inc. , BRANDENBURG, Joerg
IPC分类号： C07K1/00 , C07K1/08 , C07B37/10 , C07D265/32 , C07D207/10 , B01J31/22 , C07K5/08
CPC分类号： B01J31/2226 , B01J31/2265 , B01J31/2404 , B01J2231/543 , B01J2531/821 , C07D491/08 , C07K1/006 , C07K1/086 , C07K5/0804 , C07K5/0812
摘要： Disclosed is a process for preparing a macrocyclic compound of the formula (I) which is carried out using an intermediate of the formula (II) wherein W, R1 through R4, D,A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
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公开(公告)号：EP2229359B1
公开(公告)日：2017-11-29
申请号：EP08857477.7
申请日：2008-12-02
发明人： MERTEN, Joern , LINZ, Guenter , SCHNAUBELT, Juergen , SCHMID, Rolf , RALL, Werner , RENNER, Svenja , REICHEL, Carsten , SCHIFFERS, Robert
IPC分类号： C07D209/34
CPC分类号： C07D209/34
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