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1.发明公开
公开(公告)号：EP4402138A1
公开(公告)日：2024-07-24
申请号：EP22785932.9
申请日：2022-09-09
发明人： GERLACH, Kai , BERTA, Daniela Gavina , FERRARA, Marco , GUTSCHE, Kirsten , MUELLER-VIEIRA, Ursula , HOBSON, Scott , RUNGE, Frank , SEMPLE, Graeme , VINTONYAK, Viktor , XIONG, Yifeng
IPC分类号： C07D403/14 , C07D417/14 , A61K31/501 , A61P25/00
CPC分类号： C07D403/14 , C07D417/14 , A61K45/06 , A61K31/497 , A61K31/433
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公开(公告)号：EP2970283B1
公开(公告)日：2020-11-11
申请号：EP14709652.3
申请日：2014-03-12
发明人： ANDERSKEWITZ, Ralf , GRAUERT, Matthias , GRUNDL, Marc , HAEBEL, Peter, Wilhelm , OOST, Thorsten , PAUTSCH, Alexander , PETERS, Stefan , BINDER, Florian , VINTONYAK, Viktor
IPC分类号： C07D471/08 , A61K31/439 , A61P11/00 , A61P17/00 , A61P27/00 , A61P15/00 , A61P37/00 , A61P35/00 , A61P31/00
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3.发明公开SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C 审中-公开取代基2-AZA-BICYCLO [2.2.1] HEPTAN-3-CARBOXYLSUREURE（BENZYL-CYAN-METHYL）-AMID-HEMMSTOFFEN VON CATHEPSIN C
公开(公告)号：EP2970283A1
公开(公告)日：2016-01-20
申请号：EP14709652.3
申请日：2014-03-12
发明人： ANDERSKEWITZ, Ralf , GRAUERT, Matthias , GRUNDL, Marc , HAEBEL, Peter, Wilhelm , OOST, Thorsten , PAUTSCH, Alexander , PETERS, Stefan , BINDER, Florian , VINTONYAK, Viktor
IPC分类号： C07D471/08 , A61K31/439 , A61P11/00 , A61P17/00 , A61P27/00 , A61P15/00 , A61P37/00 , A61P35/00 , A61P31/00
摘要： This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
摘要翻译： 本发明涉及式1的2-氮杂 - 双环[2.2.1]庚烷-3-甲酸（苄基 - 氰基 - 甲基） - 酰胺及其作为组织蛋白酶C抑制剂的用途，含有该组合物的药物组合物和方法 使用与用于治疗和/或预防与二肽基肽酶I活性相关的疾病的药剂，例如， 呼吸疾病。
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公开(公告)号：EP3191487B1
公开(公告)日：2019-08-07
申请号：EP15757523.4
申请日：2015-09-08
IPC分类号： C07D471/10 , C07D491/10 , A61K31/439 , A61P11/00
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公开(公告)号：EP3511331A1
公开(公告)日：2019-07-17
申请号：EP19155235.5
申请日：2015-09-08
IPC分类号： C07D471/10 , C07D491/10 , A61K31/439 , A61P11/00
摘要： This invention relates to a compound of formula I
wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.-
公开(公告)号：EP3494120A1
公开(公告)日：2019-06-12
申请号：EP17743064.2
申请日：2017-07-31
IPC分类号： C07D498/04 , A61K31/4355 , A61P3/04
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公开(公告)号：EP3191487A1
公开(公告)日：2017-07-19
申请号：EP15757523.4
申请日：2015-09-08
IPC分类号： C07D471/10 , C07D491/10 , A61K31/439 , A61P11/00
CPC分类号： C07D491/20 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K45/06 , A61P11/00 , C07D401/12 , C07D471/08 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D519/00
摘要： This invention relates to a compound of formula I wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
摘要翻译： 其中A和Cy具有说明书中指出的含义之一及其作为组织蛋白酶C抑制剂的用途，含有其的药物组合物以及使用其作为治疗和/或预防与二肽基肽酶I活性有关的疾病的试剂的方法 ，例如 呼吸疾病。
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