-
1.发明公开
公开(公告)号：EP4402138A1
公开(公告)日：2024-07-24
申请号：EP22785932.9
申请日：2022-09-09
发明人： GERLACH, Kai , BERTA, Daniela Gavina , FERRARA, Marco , GUTSCHE, Kirsten , MUELLER-VIEIRA, Ursula , HOBSON, Scott , RUNGE, Frank , SEMPLE, Graeme , VINTONYAK, Viktor , XIONG, Yifeng
IPC分类号： C07D403/14 , C07D417/14 , A61K31/501 , A61P25/00
CPC分类号： C07D403/14 , C07D417/14 , A61K45/06 , A61K31/497 , A61K31/433
-
公开(公告)号：EP4126850A1
公开(公告)日：2023-02-08
申请号：EP21716133.0
申请日：2021-03-29
发明人： GERLACH, Kai , BERTANI, Barbara , FERRARA, Marco , FOSSATI, Giacomo , HOBSON, Scott , LESSEL, Uta Friederike , RUNGE, Frank , SEMPLE, Graeme , MUELLER-VIEIRA, Ursula , WIPPICH, Julian , XIONG, Yifeng
IPC分类号： C07D403/14 , A61P25/00 , A61K31/501 , A61K31/506
-
公开(公告)号：EP3442958B1
公开(公告)日：2020-05-06
申请号：EP17715182.6
申请日：2017-04-07
发明人： RIETHER, Doris , FERRARA, Marco , HEINE, Niklas , LESSEL, Uta , NICHOLSON, Janet Rachel , PEKCEC, Anton
IPC分类号： C07D401/12 , C07D213/82 , C07D213/84 , C07D413/12 , C07D417/12 , C07D487/04 , C07D213/64 , A61K31/4439 , A61K31/444 , A61K31/4402 , A61K31/44 , A61P25/00
-
公开(公告)号：EP3442963A1
公开(公告)日：2019-02-20
申请号：EP17715181.8
申请日：2017-04-07
发明人： RIETHER, Doris , FERRARA, Marco , HEINE, Niklas , LESSEL, Uta , NICHOLSON, Janet Rachel , PEKCEC, Anton
IPC分类号： C07D403/12 , C07D413/12 , A61K31/497 , A61P25/00
摘要： This invention relates to compounds of formula (I) a process for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions having an association with the orexin sub-type 1 receptor. Ar, R1, R2 and R3 have meanings given in the description.
-
5.发明公开MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS 审中-公开吗啉和1,4-OXAZEPANE酰胺类作为生长抑素受体亚型4（SSTR4）激动剂
公开(公告)号：EP3218372A1
公开(公告)日：2017-09-20
申请号：EP15793840.8
申请日：2015-11-12
IPC分类号： C07D413/12 , C07D471/04 , C07D265/30 , C07D267/10 , A61P29/00 , A61K31/4353
CPC分类号： C07D267/10 , A61K31/5377 , A61K31/55 , C07D265/30 , C07D413/12 , C07D471/04
摘要： The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture of the compounds according to the invention.
摘要翻译： 本发明涉及通式（I）的吗啉和1,4-氧杂氮杂环庚烷酰胺衍生物，它们是生长抑素受体亚型4（SSTR4）的激动剂，用于预防或治疗与SSTR4相关的医学病症。 另外，本发明涉及制备药物组合物的方法以及制备本发明化合物的方法。
-
6.发明公开PHENYL-3-AZA-BICYCLO[3.1.0]HEX-3-YL-METHANONES AND THE USE THEREOF AS MEDICAMENT 有权苯甲酰基-3-AZA-BICYCLO [3.1.0] HEX-3-YL-METHANONE UND DEREN VERWENDUNG ALS MEDIKAMENT
公开(公告)号：EP2739615A1
公开(公告)日：2014-06-11
申请号：EP12741022.3
申请日：2012-08-02
发明人： GIOVANNINI, Riccardo , BERTANI, Barbara , FERRARA, Marco , LINGARD, Iain , MAZZAFERRO, Rocco , ROSENBROCK, Holger
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K31/421 , A61K31/427 , A61K31/437 , A61K31/4439 , A61P25/18 , A61P25/28
CPC分类号： C07D413/04 , C07D209/52 , C07D401/04 , C07D403/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： The present inventions relates to substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl- methanones of general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 and R
6 are as herein described or salts thereof, preferably pharmaceutically acceptable salts thereof. The invention further relates to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various conditions such as conditions concerning positive and negative symptoms of schizophrenia as well as cognitive impairments associated with schizophrenia, Alzheimers Disease and other neurological and psychiatric disorders. The compounds of the invention show glycine transporter-1 (GlyT1) inhibiting properties.摘要翻译： 甘氨酸转运体-1（GlyT1）抑制剂的取代苯基-3-氮杂 - 双环[3.1.0]己-3-基 - 甲酮。 这些可用于治疗精神分裂症，阿尔茨海默病和其他神经和精神疾病。
-
公开(公告)号：EP3442964B1
公开(公告)日：2020-05-06
申请号：EP17716207.0
申请日：2017-04-07
发明人： RIETHER, Doris , FERRARA, Marco , HEINE, Niklas , LESSEL, Uta , NICHOLSON, Janet Rachel , PEKCEC, Anton , SCHEUERER, Stefan
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D239/42 , C07D413/12 , A61K31/506 , A61P25/00 , C07D403/04
-
公开(公告)号：EP3442963B1
公开(公告)日：2020-05-06
申请号：EP17715181.8
申请日：2017-04-07
发明人： RIETHER, Doris , FERRARA, Marco , HEINE, Niklas , LESSEL, Uta , NICHOLSON, Janet Rachel , PEKCEC, Anton
IPC分类号： C07D403/12 , C07D413/12 , A61K31/497 , A61P25/00
-
公开(公告)号：EP3442966A1
公开(公告)日：2019-02-20
申请号：EP17716838.2
申请日：2017-04-07
发明人： RIETHER, Doris , FERRARA, Marco , HEINE, Niklas , LESSEL, Uta , NICHOLSON, Janet Rachel , PEKCEC, Anton , SCHEUERER, Stefan
IPC分类号： C07D403/12 , C07D401/12 , C07D417/12 , A61K31/506 , A61K31/4439 , A61P25/00 , A61K51/00
-
公开(公告)号：EP3218371B1
公开(公告)日：2018-09-26
申请号：EP15793839.0
申请日：2015-11-12
IPC分类号： C07D413/12 , C07D267/14 , C07D498/04 , C07D519/00 , A61K31/553 , A61P19/02 , A61P23/00
CPC分类号： C07D471/04 , C07D267/14 , C07D413/12 , C07D498/04 , C07D519/00
摘要： The invention relates to aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amide derivatives of general formula (l),which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention relates processes for manufacture of the compounds according to the invention.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.02 秒)
