公开(公告)号：EP2068878A2

公开(公告)日：2009-06-17

申请号：EP07814835.0

申请日：2007-09-13

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： BOSANAC, Todd ,  GINN, John, David ,  HICKEY, Eugene, Richard ,  KIRRANE, Thomas, Martin ,  LIU, Weimin ,  PROKOPOWICZ, Anthony, S. ,  SHIH, Cheng-kon ,  SNOW, Roger, John ,  TURNER, Michael, Robert ,  WU, Frank ,  YOUNG, Erick, Richard ,  SCHLYER, Sabine, K.

IPC分类号： A61K31/472 ,  A61K31/517 ,  A61P9/00

CPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61P9/00 ,  A61P27/06 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/08

摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-isoquinolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.