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公开(公告)号：EP2321274A1
公开(公告)日：2011-05-18
申请号：EP09789924.9
申请日：2009-06-24
发明人： BENTZIEN, Joerg, Martin , BOYER, Stephen, James , BURKE, Jennifer , ELDRUP, Anne, Bettina , GUO, Xin , HUBER, John, David , KIRRANE, Thomas, Martin , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David
IPC分类号： C07D207/09 , C07D211/34 , C07D211/82 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
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公开(公告)号：EP2068878A2
公开(公告)日：2009-06-17
申请号：EP07814835.0
申请日：2007-09-13
发明人： BOSANAC, Todd , GINN, John, David , HICKEY, Eugene, Richard , KIRRANE, Thomas, Martin , LIU, Weimin , PROKOPOWICZ, Anthony, S. , SHIH, Cheng-kon , SNOW, Roger, John , TURNER, Michael, Robert , WU, Frank , YOUNG, Erick, Richard , SCHLYER, Sabine, K.
IPC分类号： A61K31/472 , A61K31/517 , A61P9/00
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/00 , A61P27/06 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-isoquinolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
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