公开(公告)号：EP1615947A2

公开(公告)日：2006-01-18

申请号：EP04759130.0

申请日：2004-04-06

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co.KG

发明人： DONSBACH, Kai ,  ECKER, Dieter ,  FRUTOS, Rogelio., Boehringer Ingelheim PharmaInc. ,  GALLOU, Fabrice, Boehringer Ingelheim Pharma. Inc. ,  GUTHEIL, Dieter ,  HADDAD, Nizar, Boehringer Ingelheim Pharma. Inc. ,  HAGENKOETTER, Robert ,  KEMMER, Dirk ,  KROEBER, Jutta ,  NICOLA, Thomas ,  SCHNAUBELT, Juergen ,  SCHUL, Michael ,  SIMPSON, Robert, Donald ,  WEI, Xudong, Boehringer Ingelheim Pharma. Inc. ,  WINTER, Eric ,  XU, Yibo, Boehringer Ingelheim Pharmaceuticals Inc ,  YEE, Nathan, K., Boehringer Ingelheim Pharma. Inc. ,  BRANDENBURG, Joerg

IPC分类号： C07K1/00 ,  C07K1/08 ,  C07B37/10 ,  C07D265/32 ,  C07D207/10 ,  B01J31/22 ,  C07K5/08

CPC分类号： B01J31/2226 ,  B01J31/2265 ,  B01J31/2404 ,  B01J2231/543 ,  B01J2531/821 ,  C07D491/08 ,  C07K1/006 ,  C07K1/086 ,  C07K5/0804 ,  C07K5/0812

摘要： Disclosed is a process for preparing a macrocyclic compound of the formula (I) which is carried out using an intermediate of the formula (II) wherein W, R1 through R4, D,A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.