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公开(公告)号：EP3700902A1
公开(公告)日：2020-09-02
申请号：EP18800513.6
申请日：2018-10-25
发明人： BOUYSSOU, Thierry , GOTTSCHLING, Dirk , HEINE, Niklas , SMITH KEENAN, Lana Louise , LOWE, Michael D. , RAZAVI, Hossein , SARKO, Christopher Ronald , SURPRENANT, Simon , TAKAHASHI, Hidenori , TURNER, Michael Robert , WU, Xinyuan
IPC分类号： C07D401/14 , C07D213/04 , A61K31/45 , A61K31/501
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公开(公告)号：EP3131902A1
公开(公告)日：2017-02-22
申请号：EP15718330.2
申请日：2015-04-10
发明人： BAKONYI, Johanna , BRUNETTE, Steven Richard , COLLIN, Delphine , HUGHES, Robert Owen , LI, Xiang , LIANG, Shuang , SIBLEY, Robert , TURNER, Michael Robert , WU, Lifen , ZHANG, Qiang
IPC分类号： C07D475/10 , A61K31/33
CPC分类号： C07D475/00 , A61K31/33 , C07D475/10 , C07D487/04
摘要： The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
摘要翻译： 本发明包括式（I）的化合物，其中本文所定义的变量适用于RORγ的调节和治疗与RORγ调节相关的疾病。 本发明还包括制备式（I）化合物和含有它们的药物制剂的方法。
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公开(公告)号：EP3356366A1
公开(公告)日：2018-08-08
申请号：EP16778622.7
申请日：2016-09-28
发明人： BRUNETTE, Steven Richard , CSENGERY, Johanna , HUGHES, Robert Owen , LI, Xiang , SIBLEY, Robert , TURNER, Michael Robert , XIONG, Zhaoming
IPC分类号： C07D475/10 , A61K31/519 , A61P43/00 , A61P3/10 , A61P17/00 , A61P17/06 , A61P19/02
CPC分类号： C07D475/00 , A61K31/519 , C07D475/10
摘要： The present invention encompasses compounds of formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
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公开(公告)号：EP2686310B1
公开(公告)日：2017-12-13
申请号：EP12711504.6
申请日：2012-03-13
发明人： ABEYWARDANE, Asitha , BURKE, Michael J. , KIRRANE, Thomas Martin, Jr. , NETHERTON, Matthew Russell , PADYANA, Anil Kumar , SMITH KEENAN, Lana Louise , TAKAHASHI, Hidenori , TURNER, Michael Robert , ZHANG, Qiang , ZHANG, Qing
IPC分类号： C07D319/20 , C07D405/10 , C07D487/10 , C07D405/12 , C07D405/14 , A61K31/357 , A61P29/00 , A61P19/00
CPC分类号： C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
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公开(公告)号：EP2424858B1
公开(公告)日：2014-05-14
申请号：EP10715474.2
申请日：2010-04-27
发明人： GINN, John David , MARSHALL, Daniel Richard , PROKOPOWICZ, Anthony S. , SCHYLER, Sabine , SIBLEY, Robert , TURNER, Michael Robert , WU, Di , WU, Frank
IPC分类号： C07D401/12 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04 , A61K31/19 , A61P29/00
CPC分类号： C07D403/06 , C07D401/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
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公开(公告)号：EP3356366B1
公开(公告)日：2019-08-28
申请号：EP16778622.7
申请日：2016-09-28
发明人： BRUNETTE, Steven Richard , CSENGERY, Johanna , HUGHES, Robert Owen , LI, Xiang , SIBLEY, Robert , TURNER, Michael Robert , XIONG, Zhaoming
IPC分类号： C07D475/10 , A61K31/519 , A61P43/00 , A61P3/10 , A61P17/00 , A61P17/06 , A61P19/02
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公开(公告)号：EP3131902B1
公开(公告)日：2019-06-12
申请号：EP15718330.2
申请日：2015-04-10
发明人： BAKONYI, Johanna , BRUNETTE, Steven Richard , COLLIN, Delphine , HUGHES, Robert Owen , LI, Xiang , LIANG, Shuang , SIBLEY, Robert , TURNER, Michael Robert , WU, Lifen , ZHANG, Qiang
IPC分类号： C07D475/00 , C07D487/04 , C07D475/10 , A61K31/33
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8.发明授权
公开(公告)号：EP3405470B1
公开(公告)日：2020-07-15
申请号：EP17701982.5
申请日：2017-01-18
发明人： COLLIN, Delphine , CSENGERY, Johanna , HUGHES, Robert Owen , TURNER, Michael Robert , WU, Lifen
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P37/06 , A61P37/08
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公开(公告)号：EP2686310A1
公开(公告)日：2014-01-22
申请号：EP12711504.6
申请日：2012-03-13
发明人： ABEYWARDANE, Asitha , BURKE, Michael J. , KIRRANE, Thomas Martin, Jr. , NETHERTON, Matthew Russell , PADYANA, Anil Kumar , SMITH KEENAN, Lana Louise , TAKAHASHI, Hidenori , TURNER, Michael Robert , ZHANG, Qiang , ZHANG, Qing
IPC分类号： C07D319/20 , C07D405/10 , C07D487/10 , C07D405/12 , C07D405/14 , A61K31/357 , A61P29/00 , A61P19/00
CPC分类号： C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要： The present invention relates to compounds of formula (I): wherein R
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.摘要翻译： 本发明涉及式（I）的化合物：其中R 1至R 3，A，X和n如本文所定义。 式（I）化合物可用作白三烯A 4水解酶（LTA 4 H）的抑制剂和治疗LTA 4 H相关疾病。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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10.发明公开SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXAMIDE COMPOUNDS, THEIR PREPARATION AND USE 审中-公开取代的3-氨基噻吩并[2,3-b]吡啶-2-甲酰胺化合物及其制备和用途
公开(公告)号：EP2029608A1
公开(公告)日：2009-03-04
申请号：EP07797918.5
申请日：2007-05-31
IPC分类号： C07D495/04 , A61K31/4365 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D495/04
摘要： Disclosed are compounds of formula (I): (I) wherein R
1 and R
4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
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