摘要:
The invention relates to a novel method for bonding plastic capsules (2, 3) for inhalers, to the bonded capsules obtained thereby, and to a device for carrying out said method. The capsules obtained according to the inventive method are disposable capsules and preferably contain an individual dose of a pharmaceutical formulation which can be administered by inhalation, said formulation being in the form of powder or liquid. The shape and function of said capsules enables them to be used in powder inhalers or liquid sprays for the production of aerosols. Aerosols thus produced can be inhaled, for example, so that a pharmaceutical formulation can be administered via the pulmonary route.
摘要:
The invention relates to a powder inhaler (1) comprising a mouthpiece (2) for dispersing pharmaceutical medicinal formulations. Said powder inhaler (1) comprises an auxiliary source of energy in the form of a pressurized medium system (3) and a device for storing (6) a powdered formulation (7). A gaseous pressurized medium (8) released by the pressurized medium system (3) forms an aerosol together with the powdered formulation (7) such that the powder particles are supplied in a dispersed manner in the gaseous pressurized medium (8) when said pressurized medium system is actuated. The aim of the invention is to create a powder inhaler (1), by means of which a particle size and particle size distribution that are preferred for the inhalation as well as the highest possible proportion of fine particles are obtained. Said aim is achieved by a powder inhaler (1) that is characterized by the fact that a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1) is provided within the inhaler (1).
摘要:
The invention relates to inhalation capsules (Inhalettes) made from specific capsule material with reduced moisture content, containing the active agent tiotropium in the form of a powder preparation and characterised by an improved stability.
摘要:
The invention relates to inhalation capsules (Inhalettes) made from specific capsule material with reduced moisture content, containing the active agent tiotropium in the form of a powder preparation and characterised by an improved stability.
摘要:
The invention relates to a powder inhaler (1) comprising a mouthpiece (2) for dispersing pharmaceutical medicinal formulations. Said powder inhaler (1) comprises an auxiliary source of energy in the form of a pressurized medium system (3) and a device for storing (6) a powdered formulation (7). A gaseous pressurized medium (8) released by the pressurized medium system (3) forms an aerosol together with the powdered formulation (7) such that the powder particles are supplied in a dispersed manner in the gaseous pressurized medium (8) when said pressurized medium system is actuated. The aim of the invention is to create a powder inhaler (1), by means of which a particle size and particle size distribution that are preferred for the inhalation as well as the highest possible proportion of fine particles are obtained. Said aim is achieved by a powder inhaler (1) that is characterized by the fact that a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1) is provided within the inhaler (1).
摘要:
Method for sealing plastic capsules (consisting of at least two telescopically fitting parts) by welding, involves applying energy from a jet of hot gas or a laser beam during relative movement around the vertical axis of the overlapping regions of the capsule parts, such that the capsule material is melted (but not decomposed) in this region and the overlapping regions are securely sealed by a seam region. Independent claims are also included for: (1) capsules welded by the process; (2) a capsule holder for use in the process, consisting of at least two parts which enclose the capsule such that the region to be welded is uncovered to a width of up to 3 mm for application of the radiation; and (3) apparatus for carrying out the process, consisting of apparatus for delivering the laser beam or jet of hot gas, a capsule holder as in (ii) and apparatus (preferably part of an assembly line) for exposing the capsule holder to the energy source.
摘要:
The invention relates to a powder inhaler which works according to the Bernoulli principle with replaceable cylindrical disposable capsules acting as active substance reservoirs. The powder inhaler is essentially comprised of a preferably cylindrical capsule chamber (1) which is provided with means for laterally opening the capsule (2), an air inlet opening in the capsule chamber (1), and an air outlet opening and a mouthpiece which is arranged downstream from the air outlet opening. The capsule chamber (1) is designed in such a way that the used reservoir capsule (2) can essentially only carry out movements in a longitudinal direction when a sufficiently strong flow of air is guided through the capsule chamber (1) in a substantially parallel manner in relation to the longitudinal axis of the capsule (2). According to the invention, the inner wall of the capsule chamber (1) is uneven (3,4) in order to improve emptying of the capsule in comparison with a smooth inner surface.
摘要:
The invention relates to a nebulizer for applying preservative-free liquids on the cornea or the ocular connective tissue, comprising special eye adapters (25) for said nebulizer. The invention also relates to the use of nebulizers in ophthalmological applications. The inventive nebulizers are propellant-free.