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5 条记录 (耗时 0.019 秒)

    VON AZACYCLOALKANEN ABGELEITETE URETHANE, IHRE THIO- UND DITHIOANALOGA, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS 2,3-EPOXISQUALEN-LANOSTEROL-CYCLASE INHIBITOREN
    3.
    发明公开
    VON AZACYCLOALKANEN ABGELEITETE URETHANE, IHRE THIO- UND DITHIOANALOGA, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS 2,3-EPOXISQUALEN-LANOSTEROL-CYCLASE INHIBITOREN 有权
    衍生氮杂环烷烃氨酯您的硫和DITHIOANALOGA，生产及其作为2,3-环氧角鲨烯 - 羊毛甾醇环化酶抑制剂的

    公开(公告)号：EP1060162A1

    公开(公告)日：2000-12-20

    申请号：EP98962423.4

    申请日：1998-12-08

    申请人： Boehringer Ingelheim Pharma KG

    发明人： MAIER, Roland ,  MÜLLER, Peter ,  SCHILCHER, Gebhard ,  ADELGOSS, Gebhard ,  HURNAUS, Rudolf ,  MARK, Michael ,  EISELE, Bernhard

    IPC分类号： C07D211/54 ,  C07D211/32 ,  C07D211/26 ,  C07D211/70 ,  A61K31/445

    CPC分类号： C07D211/26 ,  A23K20/132 ,  A23K50/75 ,  C07D211/54

    摘要： The present invention relates to urethanes derived from azacycloalkanes in addition to thio and dithio analogues of general formula (I), wherein m= 0 or 1, n=1or 2, A is a single bond, a straight-chain or branched C1-8 alkylene group, a C2-8 alkenylene or C2-8 alkylene group, whereby an unsaturated group is not directly bonded to radical Y; X and Y is an oxygen or sulphur atom, R?1 and R2¿ are a straight-chain or branched C¿1-6? alkyl group, a C1-4 alkenyl group or a C1-4 alkinyl group, whereby a multiple bond is isolated from the nitrogen-carbon bond, or R?1 and R2 ¿together with the nitrogen atom represent a 5-7 membered saturated heterocyclic ring, whereby one methylene group isolated from the nitrogen atom can be replaced by an oxygen or sulphur atom or by an -NH or -N (alkyl) group, R3-R6 can be identical or different and represent hydrogen atoms or alkyl groups, R7 is a C¿3-7? cycloalkyl group, optionally a phenyl or naphtyl group substituted by two halogen atoms, an alkyl, alkoxy, trifluoromethyl or cyano group or a hydrogen atom, provided that A does not represent a single bond, E is an oxygen or sulphur atom, a methylene, carbonyl or sulfinyl group and R?8¿ represents a hydrogen atom or E represents the -C(R9R10)- group, wherein R10 and adjacent group R8 represent a carbon-carbon bond. The invention also relates to enantiomers, diastereomers and salts thereof, especially physiologically acceptable acid additive salts with valuable properties such as exhibiting an inhibiting effect on cholesterol biosynthesis, in addition to medicaments containing said compounds, the use thereof and a method for the production thereof.

    VON AZACYCLOALKANEN ABGELEITETE URETHANE, IHRE THIO- UND DITHIOANALOGA, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS 2,3-EPOXISQUALEN-LANOSTEROL-CYCLASE INHIBITOREN
    5.
    发明授权
    VON AZACYCLOALKANEN ABGELEITETE URETHANE, IHRE THIO- UND DITHIOANALOGA, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS 2,3-EPOXISQUALEN-LANOSTEROL-CYCLASE INHIBITOREN 有权
    衍生氮杂环烷烃氨酯您的硫和DITHIOANALOGA，生产及其作为2,3-环氧角鲨烯 - 羊毛甾醇环化酶抑制剂的

    公开(公告)号：EP1060162B1

    公开(公告)日：2003-03-19

    申请号：EP98962423.4

    申请日：1998-12-08

    申请人： Boehringer Ingelheim Pharma KG

    发明人： MAIER, Roland ,  MÜLLER, Peter ,  SCHILCHER, Gebhard ,  ADELGOSS, Gebhard ,  HURNAUS, Rudolf ,  MARK, Michael ,  EISELE, Bernhard

    IPC分类号： C07D211/54 ,  C07D211/32 ,  C07D211/26 ,  C07D211/70 ,  A61K31/445

    CPC分类号： C07D211/26 ,  A23K20/132 ,  A23K50/75 ,  C07D211/54

    摘要： The present invention relates to urethanes derived from azacycloalkanes in addition to thio and dithio analogues of general formula (I), wherein m= 0 or 1, n=1or 2, A is a single bond, a straight-chain or branched C1-8 alkylene group, a C2-8 alkenylene or C2-8 alkylene group, whereby an unsaturated group is not directly bonded to radical Y; X and Y is an oxygen or sulphur atom, R?1 and R2¿ are a straight-chain or branched C¿1-6? alkyl group, a C1-4 alkenyl group or a C1-4 alkinyl group, whereby a multiple bond is isolated from the nitrogen-carbon bond, or R?1 and R2 ¿together with the nitrogen atom represent a 5-7 membered saturated heterocyclic ring, whereby one methylene group isolated from the nitrogen atom can be replaced by an oxygen or sulphur atom or by an -NH or -N (alkyl) group, R3-R6 can be identical or different and represent hydrogen atoms or alkyl groups, R7 is a C¿3-7? cycloalkyl group, optionally a phenyl or naphtyl group substituted by two halogen atoms, an alkyl, alkoxy, trifluoromethyl or cyano group or a hydrogen atom, provided that A does not represent a single bond, E is an oxygen or sulphur atom, a methylene, carbonyl or sulfinyl group and R?8¿ represents a hydrogen atom or E represents the -C(R9R10)- group, wherein R10 and adjacent group R8 represent a carbon-carbon bond. The invention also relates to enantiomers, diastereomers and salts thereof, especially physiologically acceptable acid additive salts with valuable properties such as exhibiting an inhibiting effect on cholesterol biosynthesis, in addition to medicaments containing said compounds, the use thereof and a method for the production thereof.