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1.发明授权
公开(公告)号：EP2320932B1
公开(公告)日：2015-07-15
申请号：EP09791315.6
申请日：2009-08-07
IPC分类号： A61K38/17 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/47 , A61K39/00 , G01N33/68 , G01N33/574 , C12N15/11 , A61P35/00
CPC分类号： A61K38/08 , A61K38/10 , A61K38/1709 , A61K39/0011 , G01N33/574 , Y02A50/394
摘要： The present invention provides methods of predicting the relative growth rate, replication rate, or lethality of a first malignancy as compared to another malignancy or as compared to a plurality of malignancies, including methods of predicting the relative growth rate, replication rate, or relative lethality of a primary malignancy as compared to a metastatic malignancy, including comparing the concentration of Replikin sequences in the first malignancy with the concentration of Replikin sequences in another malignancy or malignancies and further provides Replikin peptides and Replikin Peak Genes identified within a malignancy for diagnostic, therapeutic, preventive, and predictive purposes.
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2.发明公开PEPTIDES SHARED AMONG LETHAL CANCERS AND THERAPEUTIC COMPOSITIONS COMPRISING SAID PEPTIDES 审中-公开与这些肽致死和治疗组合物常见的癌症肽
公开(公告)号：EP2734226A2
公开(公告)日：2014-05-28
申请号：EP12743590.7
申请日：2012-07-19
CPC分类号： A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K16/30
摘要： The present invention provides cancer peptides related to rapid replication and shared among different histological cancer types. The peptides are provided in compositions for interfering with replication in cancer, in preventive and therapeutic vaccines, and in diagnostic applications. The compositions for interfering with replication in cancer are useful for preventing and treating different histological types of cancer including ectodermic, endodermic, and mesodermic cancers as well as cancers arising in association with HIV.
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3.发明公开System and method for identifying complex replikin patterns of amino acids 审中-公开用于鉴定复杂的复制氨基酸模式的系统和方法
公开(公告)号：EP2390808A2
公开(公告)日：2011-11-30
申请号：EP11158102.1
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译： 公开了用于识别和/或定位存储在数据库的计算机文件中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进对蛋白质数据库的查询的技术。 对于响应于查询而接收的蛋白质描述，本发明的实施例可以扫描所接收的蛋白质描述以识别和定位Replikin模式。 Replikin模式被定义为包括以下三个（3）特征的7至约50个氨基酸的序列，其中每个特征可以被本发明的实施方式识别：（1）所述序列具有至少一个赖氨酸 残基位于来自第二赖氨酸残基的六至十个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。
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4.发明公开System and method for identifying complex replikin patterns of amino acids 审中-公开系统与Verfahren zur Identifizierung komplexerAminosäurenreplikinstrukturen
公开(公告)号：EP2390806A2
公开(公告)日：2011-11-30
申请号：EP11158093.2
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases.For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译： 公开了用于识别和/或定位存储在数据库的计算机文件中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了技术来促进蛋白质数据库的查询。对于响应于查询而接收的蛋白质描述，本发明的实施方案可以扫描接收的蛋白质描述以识别和定位复制素模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。
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公开(公告)号：EP2390805A2
公开(公告)日：2011-11-30
申请号：EP11158084.1
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
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6.发明公开
公开(公告)号：EP2320932A2
公开(公告)日：2011-05-18
申请号：EP09791315.6
申请日：2009-08-07
IPC分类号： A61K38/17 , A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/47 , A61K39/00 , G01N33/68 , G01N33/574 , C12N15/11 , A61P35/00
CPC分类号： A61K38/08 , A61K38/10 , A61K38/1709 , A61K39/0011 , G01N33/574 , Y02A50/394
摘要： The present invention provides methods of predicting the relative growth rate, replication rate, or lethality of a first malignancy as compared to another malignancy or as compared to a plurality of malignancies, including methods of predicting the relative growth rate, replication rate, or relative lethality of a primary malignancy as compared to a metastatic malignancy, including comparing the concentration of Replikin sequences in the first malignancy with the concentration of Replikin sequences in another malignancy or malignancies and further provides Replikin peptides and Replikin Peak Genes identified within a malignancy for diagnostic, therapeutic, preventive, and predictive purposes.
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7.发明公开System and method for identifying complex replikin patterns of amino acids 审中-公开系统和方法，用于识别复杂Aminosäurenreplikinstrukturen
公开(公告)号：EP2390808A3
公开(公告)日：2012-02-29
申请号：EP11158102.1
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
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公开(公告)号：EP2390807A3
公开(公告)日：2012-02-29
申请号：EP11158097.3
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three ( 3 ) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
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公开(公告)号：EP2390805A3
公开(公告)日：2012-02-29
申请号：EP11158084.1
申请日：2005-04-28
CPC分类号： G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file of database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
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10.发明公开SYNTHETIC REPLIKIN PEPTIDES AGAINST PATHOGENIC INFECTION OF INVERTEBRATES IN AQUACULTURE 审中-公开合成的Replikin肽抗感染致病性无脊椎动物水产养殖
公开(公告)号：EP2167122A2
公开(公告)日：2010-03-31
申请号：EP08825968.4
申请日：2008-04-23
CPC分类号： A61K39/125 , A61K38/08 , A61K38/10 , A61K38/162 , A61K39/00 , A61K39/12 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/72 , C12N2710/18022 , C12N2760/16022 , C12N2770/22022 , C12N2770/24122 , C12N2770/32022 , C12N2770/32034
摘要： The present invention provides isolated or synthesized peptides of about 7 to about 50 amino acids identified in the genome of pathogens in invertebrates in aquaculture for prevention and treatment of outbreaks of these pathogens in aquaculture and methods of preventing and treating pathogenic outbreaks using the identified peptides.
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