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    A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS
    1.
    发明公开
    A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS 审中-公开
    一组新的STAT3途径抑制剂和癌症干细胞通路抑制剂

    公开(公告)号：EP3050566A2

    公开(公告)日：2016-08-03

    申请号：EP16156335.8

    申请日：2008-09-10

    申请人： Boston Biomedical, Inc.

    发明人： LI, Chiang, Jia ,  JIANG,, Zhiwei ,  ROGOFF, Harry ,  LI, Youzhi ,  LIU, Jifeng ,  LI, Wei

    IPC分类号： A61K31/505 ,  A61K31/55 ,  A61K38/17 ,  A61P35/00

    CPC分类号： C07D307/92 ,  A61K31/38 ,  C07D333/74 ,  Y02A50/465

    摘要： The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regiment; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds.

    摘要翻译： 本发明涉及一类新型癌症干细胞通路（CSCP）抑制剂的用途; 涉及使用这些化合物来治疗难治性，复发性或转移性癌症的方法; 通过使用具有特定给药方案的这种化合物选择性杀死癌细胞的方法; 涉及通过抑制Stat3途径靶向癌症干细胞的方法; 涉及使用新化合物治疗哺乳动物与异常Stat3途径活性有关的病症或障碍的方法; 并涉及制备这些化合物及其中间体的方法，以及相关化合物的药物组合物，以及这些化合物的具体给药方法。