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公开(公告)号：EP3058941B1
公开(公告)日：2019-05-22
申请号：EP16156290.5
申请日：2008-09-10
发明人： JIANG, Zhiwei , LI, Chiang, Jia , LI, Wei , LEGGETT, David
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17
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公开(公告)号：EP2547205A1
公开(公告)日：2013-01-23
申请号：EP11757135.6
申请日：2011-03-21
发明人： LI, Chiang, Jia , LEGGETT, David , LI, Youzhi , LI, Wei
CPC分类号： A61K31/343
摘要： The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.
摘要翻译： 本发明提供了萘并呋喃化合物，萘并呋喃化合物的多晶型物，颗粒形式的萘并呋喃化合物，含有一种或多种萘并呋喃化合物的纯化组合物，含有一种或多种颗粒形式的萘并呋喃化合物的纯化组合物，生产这些萘并呋喃化合物的方法，多晶型物， 组合物和/或颗粒形式，以及使用这些萘并呋喃化合物，多晶型物，纯化的组合物和/或颗粒形式来治疗有需要的受试者的方法。
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公开(公告)号：EP2194987A2
公开(公告)日：2010-06-16
申请号：EP08830471.2
申请日：2008-09-10
发明人： JIANG, Zhiwei , LI, Chiang, Jia , LI, Wei , LEGGETT, David
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
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公开(公告)号：EP2193140A2
公开(公告)日：2010-06-09
申请号：EP08828867.5
申请日：2008-08-27
发明人： LI, Chiang, Jia , SUN, Xiangao , ROGOFF, Harry , LI, Youzhi
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51
摘要： The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5 '-overhang, 3 '-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
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公开(公告)号：EP3058941A1
公开(公告)日：2016-08-24
申请号：EP16156290.5
申请日：2008-09-10
发明人： JIANG, Zhiwei , LI, Chiang, Jia , LI, Wei , LEGGETT, David
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrant Stat3 pathway activity; to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及作为Stat3途径抑制剂和作为癌症干细胞抑制剂的新型萘并萘类化合物; 涉及使用这些化合物治疗癌症的方法; 涉及使用此类化合物治疗与异常Stat3途径活性有关的哺乳动物病症的方法; 涉及含有这些化合物的药物组合物
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公开(公告)号：EP2200431A1
公开(公告)日：2010-06-30
申请号：EP08830633.7
申请日：2008-09-10
发明人： LI, Chiang, Jia , MIKULE, Keith , LI, Youzhi
IPC分类号： A01N31/14
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
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7.发明公开A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS 有权STAT3 PATH抑制剂和癌症干细胞PATH抑制剂的新群
公开(公告)号：EP2190429A1
公开(公告)日：2010-06-02
申请号：EP08830619.6
申请日：2008-09-10
发明人： LI, Chiang, Jia , JIANG, Zhiwei , ROGOFF, Harry , LI, Youzhi , LIU, Jifeng , LI, Wei
IPC分类号： A61K31/38
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
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公开(公告)号：EP3050566B1
公开(公告)日：2018-11-28
申请号：EP16156335.8
申请日：2008-09-10
发明人： LI, Chiang, Jia , JIANG, Zhiwei , ROGOFF, Harry , LI, Youzhi , LIU, Jifeng , LI, Wei
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17 , A61P35/00
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
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9.发明授权COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES 有权激酶抑制剂的组合物及其用途癌症和其他与相关的疾病在连接激酶治疗
公开(公告)号：EP2197878B1
公开(公告)日：2016-08-17
申请号：EP08829600.9
申请日：2008-09-05
发明人： LI, Chiang, Jia , LIU, Ji-Feng , LI, Youzhi , LI, Wei , ROGOFF, Harry
IPC分类号： C07D417/04 , A61K45/06 , A61K31/4439 , A61K31/496 , A61K31/427 , C07D417/14
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K45/06 , C07D417/04
摘要： The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
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10.发明公开COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES 审中-公开激酶抑制剂的组合物及其用途癌症和其他与相关的疾病在连接激酶治疗
公开(公告)号：EP3037419A1
公开(公告)日：2016-06-29
申请号：EP16156340.8
申请日：2008-09-05
发明人： LI, Chiang, Jia , LIU, Ji-Feng , LI, Youzhi , LI, Wei , ROGOFF, Henry
IPC分类号： C07D417/02 , C07D209/34 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K45/06 , C07D417/04
摘要： The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
摘要翻译： 本发明涉及新的噻唑substituiertem二氢吲哚-2-酮作为CSCPK的抑制剂和相关激酶; 通过使用激酶抑制剂癌症抑制干细胞的方法; 向含有试验化合物的药物组合物; 以及使用在哺乳动物相关病症治疗蛋白激酶的搜索的化合物的方法; 以及制造测试的化合物和其中间体的方法。
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