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1.发明公开
公开(公告)号：EP1062000A1
公开(公告)日：2000-12-27
申请号：EP99909703.3
申请日：1999-03-01
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61M25/0138 , A61M25/1002 , A61M25/104 , A61M2025/0063 , A61M2025/0656 , A61M2025/1061 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source (24) for inhibiting restenosis including a radiation delivery tube (20) having a radioactive distal region (24), the tube (20) being adapted to slide over a core wire (28) within a radiation delivery catheter (42). The core wire (28) is preferably in a slidable relation with the radiation delivery catheter (42). By withdrawing the core wire (28) to a proximal position, the flexibility of a distal region of the radiation delivery catheter (42) may be increased, thereby allowing the radiation delivery catheter (42) to navigate more tortuous paths and reach more distal sites. Before the radiation delivery tube (20) is advanced into the catheter distal region, the core wire (28) is preferably slid distally to a distal position. With the core wire (28) in the distal position, the core wire (28) may provide a structure that can be used to rapidly advance the radiation source (24) to the lesion site. The core wire (28) may also help constrain lateral movement of the radiation delivery tube (20) and help center the radiation delivery tube (20) within the vessel to provide a more even radiation exposure to the vessel walls.
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公开(公告)号：EP1973605A2
公开(公告)日：2008-10-01
申请号：EP06847612.6
申请日：2006-12-14
发明人： KVEEN, Graig, L. , HASTINGS, Roger, N. , SADASIVA, Anupama , SHAPOVALOV, Vitaly, N. , LAFONTAINE, Daniel, M.
IPC分类号： A61N1/378
CPC分类号： A61N1/056 , A61F2/88 , A61F2002/828 , A61F2250/0001 , A61N1/0565 , A61N1/057 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： Apparatus, system, and method that include a pacing apparatus having a stent electrode through which pulses of electrical current can be delivered. Stent electrodes receive energy for generating the electrical current from a variety of sources. Sources include from one or more induction coils that can form at least a portion of the stent. Sources can also include an implantable pulse generator coupled to a lead through which pulses of the electrical current are supplied to the stent electrodes.
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公开(公告)号：EP2063954A2
公开(公告)日：2009-06-03
申请号：EP07838306.4
申请日：2007-09-14
发明人： ATANASOSKA, Liliana, L. , WEBER, Jan , HASTINGS, Roger, N. , WARNER, Robert, W. , POLKINGHORNE, Jeannette, C. , MILLER, Matthew , J.
IPC分类号： A61N1/05
摘要： An electrode with an electrode surface having a polyoxometalate (POM). The use of POM with an electrode surface increases the active electrochemical surface area, with a resulting increase in capacitance and impedance, and a decrease of polarization losses at the electrode/tissue interface. In addition, electrodes having POM can include pseudo-capacitive properties from their redox properties and charge storage properties.
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公开(公告)号：EP1019144A1
公开(公告)日：2000-07-19
申请号：EP98902397.3
申请日：1998-01-08
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61N2005/1004
摘要： This invention is a device and method for irradiating human body vessel interior walls. One device (21) includes a beta radiation emitting segmented metal tube disposed at the distal end of an elongate shaft (38). Another device (121) includes a radioactive elastic sleeve (140) mounted on a shaft (138). The device (121) can be used to inhibit restenosis following angioplasty in coronary arteries. In use, the device (121) can be advanced distally over the balloon (44) portion of a positioned and deflated angioplasty balloon catheter (20), whereupon the balloon (44) is inflated, pressing the radiation device into close contact with the vessel walls. After a desired exposure period, the balloon (44) is deflated, and the device (21), biased to contract, contracts with the balloon (44), allowing for ease of withdrawal from the patient.
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公开(公告)号：EP1011787A1
公开(公告)日：2000-06-28
申请号：EP98903431.9
申请日：1998-01-07
发明人： HASTINGS, Roger, N.
IPC分类号： A61N1/00
CPC分类号： A61M25/0127 , A61M25/1002 , A61M2025/0177 , A61M2025/1047 , A61M2025/105 , A61M2025/1095 , A61N5/1002 , A61N2005/1003
摘要： This invention is an intravascular radiation delivery system (10) including a catheter (11), a radiation source (14), disposed in an open-ended lumen (12) in the catheter (11), and a closed-ended sheath (13) surrounding the radiation source (14), so as to prevent blood and other fluids from coming into contact with the radiation source (14). Preferably, the open-ended lumen (12) is centered in the balloon (15) for uniform radiation delivery. The catheter (11) may include a blood perfusion lumen under the balloon (15) or around the balloon (15). The open-ended lumen (12) in the catheter (11) may have a reduced diameter adjacent the distal end of the catheter (11) to prevent the radiation source (14) from exiting the lumen. Methods of using the radiation delivery system (10) are also disclosed, such as an alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.
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公开(公告)号：EP1835962B1
公开(公告)日：2015-04-22
申请号：EP05817448.3
申请日：2005-10-19
CPC分类号： A61N1/37223 , A61N1/0587 , A61N1/08 , A61N1/3627 , A61N1/375 , A61N1/3756 , A61N1/3787
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7.发明公开
公开(公告)号：EP0966227A1
公开(公告)日：1999-12-29
申请号：EP98901679.0
申请日：1998-01-02
发明人： WANG, Lixiao , HASTINGS, Roger, N.
CPC分类号： A61F2/82 , A61B2017/22002 , A61F2002/30448 , A61F2220/005 , A61K51/1279 , A61K51/1282 , A61M25/104 , A61M29/02 , A61M2025/105 , A61N5/1002
摘要： This invention is a method and composition for inhibiting restenosis. The composition (64) includes an adhesive or polymeric material having a radioactive component dispersed therethrough. The biologically compatible adhesive (64) including a radioactive material, is applied to a vessel region where inhibition of restenosis is desired.
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公开(公告)号：EP1835962A1
公开(公告)日：2007-09-26
申请号：EP05817448.3
申请日：2005-10-19
CPC分类号： A61N1/37223 , A61N1/0587 , A61N1/08 , A61N1/3627 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.
摘要翻译： 提供了采用无引线电极来提供起搏治疗的各种配置的系统。 在一个实例中，提供用于心脏心肌起搏的多个部位的系统包括无线起搏电极组件，所述无线起搏电极组件可使用经皮腔内导管递送系统在邻近心肌的部位植入。 还公开了这种系统的各种配置，无线电极组件和用于输送和植入电极组件的输送导管。
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公开(公告)号：EP1037692A1
公开(公告)日：2000-09-27
申请号：EP98960662.9
申请日：1998-12-03
IPC分类号： A61N5/00
CPC分类号： A61N5/1002 , A61M2025/0063 , A61N2005/1003 , A61N2005/1004
摘要： A radiation source for inhibiting restenosis including a radiation delivery tube (20) having a radioactive distal region (24), the tube (20) being adapted to slide over a guide wire (28) within a radiation delivery catheter (42). In use, the catheter (42) is advanced to a site to be treated, the balloon (54) inflated, and the radioactive tube (20) advanced over the radiation source guide wire (28) within the lumen (50).
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